TLDR Sorafenib may cause hand-foot and stump syndrome, requiring early detection and management.
A 47-year-old man with metastatic renal cell carcinoma developed hand-foot and stump syndrome (HFSS) after 8 weeks of treatment with sorafenib, a chemotherapeutic agent. The patient experienced tingling and developed tender, erythematous lesions on his palms, right sole, and left stump, as well as subungual splinter hemorrhages. The case suggested a possible link between sorafenib and HFSS, potentially due to the drug's concentration in eccrine sweat glands. Other adverse effects of sorafenib included seborrheic dermatitis-like rash, alopecia, and hair depigmentation. The study highlighted the need for early recognition and management of these dermatologic side effects to continue effective cancer treatment.
55 citations
,
November 2004 in “Expert opinion on drug safety” Chemotherapy often causes hair loss, nail changes, and mouth issues, but these are usually manageable.
275 citations
,
March 1999 in “Journal of The American Academy of Dermatology” Chemotherapy can cause various skin reactions, with hair loss being the most common, and proper diagnosis and treatment of these reactions are important.
7 citations
,
August 2017 in “Journal of dermatological science” Sorafenib causes skin reactions by increasing the number and activity of skin mast cells.
234 citations
,
September 2004 in “Clinical cancer research” BAY 43-9006 helps control kidney cancer growth but doesn't significantly increase overall survival.
March 2014 in “Journal of The American Academy of Dermatology” The document lists various dermatology topics, treatments, and diagnostic methods.
86 citations
,
November 2020 in “Annals of Oncology” Early intervention and tailored management can reduce skin side effects from cancer treatments.
3 citations
,
November 2018 in “Oncology issues” Cancer survivors often experience worse skin problems from treatment than expected, and working with dermatologists could help improve their condition.
