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    Did you mean Hand-Foot Syndrome?
    Glossary Hand-Foot Syndrome

    causes redness, swelling, and pain on palms and soles

    Hand-Foot Syndrome, also known as Palmar-Plantar Erythrodysesthesia (PPE), is a side effect of certain chemotherapy drugs. It causes redness, swelling, and pain on the palms of the hands and the soles of the feet, and in severe cases, can lead to blistering and peeling of the skin. This condition occurs because the chemotherapy drugs leak out of the capillaries in these areas, leading to inflammation and damage.

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      research Hand-Foot and Stump Syndrome to Sorafenib

      45 citations , January 2007 in “Journal of Clinical Oncology”
      This case report identifies hand-foot and stump syndrome as a potential side effect of sorafenib therapy in a 47-year-old man with a leg amputation.
      Kinase Inhibition with BAY 43-9006 in Renal Cell Carcinoma

      research Kinase Inhibition with BAY 43–9006 in Renal Cell Carcinoma

      234 citations , September 2004 in “Clinical cancer research”
      In this Phase II study, BAY 43–9006, taken orally for renal cell carcinoma, stabilized disease in 30% of patients, with 40% responding positively, although the targets remain unclear.
      Skin Disorders in Diabetes Mellitus

      research Skin disorders in diabetes mellitus

      September 2014 in “Journal der Deutschen Dermatologischen Gesellschaft”
      Diabetes can cause a variety of skin disorders, some of which may signal more serious health issues.
      Skin Diseases Due to Endocrine Alterations

      research Skin diseases in consequence of endocrine alterations

      16 citations , January 2006 in “The Aging Male”
      This review discusses various skin diseases with endocrinological origins and reports no clinical results, highlighting the need for interdisciplinary understanding in diagnosis.
      Sorafenib-Induced Facial Acneiform Eruption

      research Sorafenib-induced Facial Acneiform Eruption

      April 2019 in “Cureus”
      In this case report, a patient on low-dose sorafenib for hepatocellular carcinoma developed a rare and severe facial acneiform eruption without other skin side effects, which improved only minimally with topical treatment.
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