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    Glossary SAPHO syndrome

    rare disorder causing joint inflammation and severe skin conditions

    SAPHO syndrome is a rare, chronic disorder that stands for Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis. It primarily affects the skin and bones, leading to painful inflammation in the joints and skin conditions like severe acne and pustules. The exact cause is unknown, but it is believed to involve both genetic and environmental factors.

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      research [Methotrexate to treat SAPHO syndrome with keloidal scars].

      10 citations , December 2011 in “PubMed”
      In this reported case of SAPHO syndrome, methotrexate treatment led to significant clinical improvement after other treatments for skin lesions and arthritis proved less effective.

      research S4890 Infliximab-Induced Synovitis, Acne, Pustulosis, Hyperostosis, Osteitis Syndrome

      October 2025 in “The American Journal of Gastroenterology”
      This report describes a case of SAPHO syndrome likely triggered by escalated dosing of infliximab in a 21-year-old woman, highlighting the complex nature of infliximab-induced adverse events, and suggesting a potential autoimmune basis involving two distinct pathophysiologies for SAPHO syndrome.

      research Acne-Associated Syndromes

      January 2019 in “Springer eBooks”
      Acne is linked to inflammation and insulin resistance, and is associated with various syndromes that require different treatments.

      research Acne and Systemic Disease

      76 citations , November 2009 in “Medical Clinics of North America”
      This article reviews the hormonal and medication-related factors associated with acne development but does not present new research findings.