Human Macrophages Preferentially Infiltrate the Superficial Adipose Tissue

    Giuseppe Cappellano, Evi M. Morandi, Johannes Michael Rainer, Philipp Grubwieser, Katharina Heinz, Dolores Wolfram, David Bernhard, Susanne Lobenwein, Gerhard Pierer, Christian Ploner
    Image of study
    TLDR Human body's immune cells are more common in the layer of fat just beneath the skin than in deeper fat layers.
    The study focused on the differences between human superficial adipose tissue (SAT) and deep adipose tissue (DAT), particularly in terms of immune cell infiltration and the properties of adipose-derived stem cells (ASCs). It was found that SAT contained larger primary adipocytes and a higher number of tissue-infiltrating macrophages compared to DAT. ASCs from SAT also showed faster proliferation and greater differentiation potential. The study involved 14 female patients with a mean age of 43.6 years and a mean BMI of 25.1 kg/m². The findings suggest that SAT may have a higher regenerative potential and that its proximity to skin microbiota could explain the increased macrophage infiltration. This could have implications for therapeutic approaches using ASCs. However, the document also included a section that could not be parsed as it did not provide specific results or conclusions.
    Discuss this study in the Community →

    Research cited in this study

    4 / 4 results

    Related Community Posts Join

    6 / 109 results
      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      in Research  830 upvotes 9 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community Shaving is NOT accepting baldness

      in Shaved/buzzed  52 upvotes 2 years ago
      Accepting baldness and the various ways people try to cope with it, such as shaving, using medications like minoxidil and finasteride, or getting a hair transplant. Participants discussed how true acceptance of hair loss involves confronting difficult emotions such as grief for one's former appearance and identity, as opposed to simply superficially hiding it with a shaved head.

      community 24M — 4.5 Months Into Hair Treatment, Feeling Emotionally Drained

      in Is this regrowth?  85 upvotes 1 week ago
      A 24-year-old male is experiencing emotional stress from hair loss despite seeing significant progress after 4.5 months of using oral dutasteride and minoxidil, and has now switched to topical treatments. Many users encourage him to continue with the oral treatments due to his impressive results and suggest waiting at least a year before considering a hair transplant.

      community Hairloss and dandruff.. potential sebderm inflammation?

      in Research/Science  1 upvotes 1 month ago
      A 21-year-old is experiencing aggressive hair loss and dandruff, possibly due to seborrheic dermatitis, and is using pumpkin seed oil, scalp massages, and anti-dandruff shampoo as treatments. They are hesitant to use prescribed Finasteride and Minoxidil and have noticed some improvement after stopping Serenoa capsules.

    Similar Research

    5 / 1000+ results