Nanofat in Plastic Reconstructive, Regenerative, and Aesthetic Surgery: A Review of Advancements in Face-Focused Applications

Nanofat, derived from mechanically emulsified adipose tissue, shows promise in plastic, reconstructive, regenerative, and aesthetic surgery, particularly for facial applications. It improves skin quality, treats scars, and rejuvenates aged skin by leveraging adipose-derived stem cells (ASCs) and growth factors. Studies, including those with 67 and 50 patients, report significant improvements in skin texture, elasticity, and radiance, with minimal side effects and high patient satisfaction. Despite these positive outcomes, further research is needed to standardize protocols and evaluate long-term efficacy and safety.