Efficacy and Safety of Baricitinib in Adult Patients With Severe Alopecia Areata With or Without an Atopic Background From Two Randomized, Placebo-Controlled, Phase 3 Trials

September 2022 in “ Journal of the American Academy of Dermatology ”

Natasha Atanaskova Mesinkovska, Taisuke Ito, Maryanne M. Senna

baricitinib alopecia areata SALT score eyebrow regrowth eyelash regrowth atopic background

TLDR Baricitinib is effective and safe for severe alopecia areata, working similarly with or without an atopic background.

The document presents the results of two phase 3 trials (BRAVE-AA1 and BRAVE-AA2) involving 1200 patients with severe alopecia areata (AA), 37.8% of whom had an atopic background. The trials tested the efficacy and safety of baricitinib, a medication for AA. At week 36, 40.8% of patients with an atopic background who received 4-mg baricitinib achieved a Severity of Alopecia Tool (SALT) score ≤20, compared to 30.2% of those without an atopic background. Improvements in eyebrow/eyelash measures were also observed. The safety profile of baricitinib was similar in both subgroups and the overall population. The study concludes that the safety and improvements in hair regrowth in baricitinib-treated patients with severe AA were independent of atopic background.

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community What are the odds baricitinib will get a topical otc version for androgenic alopecia?

in Research/Science 1 year ago

Baricitinib, approved for alopecia areata, might be considered for treating receding hairlines. The discussion is about the possibility of an over-the-counter topical version for androgenic alopecia.

community Lilly to seek first approval of an autoimmune drug for hair loss

in Research/Science 18 upvotes 3 years ago

Eli Lilly's drug baricitinib showed effectiveness in treating alopecia areata, with higher doses resulting in significant hair regrowth compared to placebo. The treatment is not for male pattern baldness.

community Anyone else taking Litfulo (ritlecitinib) to treat their alopecia?

in Treatment 5 upvotes 1 year ago

A user diagnosed with Alopecia Areata started using Litfulo (ritlecitinib), kenalog shots, and mometasone furoate 0.1%. They shaved their head and are seeking others' experiences with Litfulo.

community I am a dermatologist with a clinical interest in alopecia. AMA

in Will treatment work for me? 2 years ago

In this conversation, 4990 discussed various treatments for hair loss, including oral minoxidil, PRP, transplan, Jak inhibitors, Dutasteride, Finasteride, Olumiant, Ketoconazole, RU58841, microneedling, baricitinib, and CCCA. They recommended scalp biopsies in unclear cases of DUPA, twice weekly to twice daily shampooing for topical minoxidil users, and two sessions spaced one month apart with follow up at month three to determine the effectiveness of PRP treatment.

community Olumiant active ingredient Baricitinib

in Research/Science 1 upvotes 2 years ago

The conversation is about someone inquiring if anyone has tried Olumiant or its active ingredient, Baricitinib, for hair loss, mentioning the cost and that they have ordered Baricitinib.

community Anyone heard of or have experience using baricitinib?

in Research/Science 1 upvotes 1 year ago

The conversation is about baricitinib, a medicine that can help with hair loss, and why it isn't more popular or widely discussed. No specific experiences with the treatment were shared.

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research Twenty Nail Dystrophy with Alopecia Areata in an Atopic Child

April 2019 in “International journal of research in dermatology”

A child with rough nails also had hair loss and allergies.