Serum Level of Interleukin-15 in Active Alopecia Areata Patients and Its Relation to Age, Sex, and Disease Severity

January 2020 in “ Advances in Dermatology and Allergology ”

Magdy Ragab, Eman Hassan, Dalia Niely, Mai Mohamed

interleukin-15 alopecia areata cytokine IL-15 AA

Studysummary This study found that elevated serum levels of IL-15 in active alopecia areata patients are correlated with disease severity, suggesting it plays a role in disease pathogenesis. Our plain-language summary of this paper — not a Tressless recommendation.

The study found that elevated serum levels of interleukin-15 (IL-15) in patients with active alopecia areata (AA) suggested its significant role in the disease's pathogenesis as a key signaling cytokine. The level of IL-15 was correlated with the severity of the disease, indicating that higher levels were associated with more severe cases of AA. However, the study concluded that IL-15 levels were not affected by the patients' gender or age.

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research JAK Inhibitors for Alopecia Areata: A Systematic Review and Meta-Analysis

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176 citations , August 2015 in “The journal of allergy and clinical immunology/Journal of allergy and clinical immunology/The journal of allergy and clinical immunology”

This study identified a distinct cytokine activation signature in alopecia areata, involving TH2, TH1, IL-23, and IL-9/TH9 pathways, suggesting potential targeting strategies similar to those in psoriasis and atopic dermatitis.

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research Serum Granulysin as a Possible Key Marker of the Activity of Alopecia Areata

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