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    Did you mean JAK3 Inhibitor?
    Glossary JAK3 Inhibitor

    blocks an enzyme involved in immune response and inflammation

    A JAK3 Inhibitor, also known as a Janus Kinase 3 Inhibitor, is a type of medication that blocks the activity of the JAK3 enzyme. This enzyme is involved in the signaling pathways that regulate immune responses and inflammation. By inhibiting JAK3, these drugs can help treat autoimmune diseases and conditions like alopecia areata, where the immune system mistakenly attacks hair follicles.

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    Research 10 of 530

    1. Efficacy and safety of ritlecitinib, an oral JAK3/TEC family kinase inhibitor, in adolescent and adult patients with alopecia totalis and alopecia universalis The Journal of Dermatology · 2024 · 7 citations
    2. Integrated Safety Analysis of Ritlecitinib, an Oral JAK3/TEC Family Kinase Inhibitor, for the Treatment of Alopecia Areata from the ALLEGRO Clinical Trial Program American journal of clinical dermatology · 2024
    3. 801 TEC family kinase inhibitors as a novel class of therapeutics in alopecia areata Journal of Investigative Dermatology · 2024
    4. 0935 Unravelling the role of JAK3/TEC kinase signalling with ritlecitinib in alopecia areata lesional skin and alopecia areata-induced human hair follicles ex vivo Journal of Investigative Dermatology · 2025
    5. 63418 JAK3/TEC kinase pathways are active in alopecia areata lesions, and their inhibition with Ritlecitinib prevents αCD3/αCD28+IL-2 induced immune privilege collapse in healthy hair follicles ex vivo Journal of the American Academy of Dermatology · 2025
    6. FDA approves Pfizer's JAK inhibitor for adolescents with alopecia areata hair loss Nature Medicine · 2023 · 4 citations
    7. Ritlecitinib in Alopecia Areata: A 24‐Week Real‐World Experience Contrasting JAK Inhibitor‐Naïve and JAK Inhibitor‐Experienced Patients The Journal of Dermatology · 2025
    8. Inhibition of T-cell activity in alopecia areata: recent developments and new directions Frontiers in immunology · 2023 · 4 citations
    9. 42004 Scalp, eyebrow, and eyelash hair regrowth with continued ritlecitinib treatment among patients with alopecia areata without target efficacy response at Week 24: post hoc analysis of the ALLEGRO phase 2b/3 study Journal of the American Academy of Dermatology · 2023 · 1 citations
    10. 42005 Sustained scalp, eyebrow, and eyelash hair regrowth with ritlecitinib through Week 48 in patients with alopecia areata: post hoc analysis of the ALLEGRO phase 2b/3 study Journal of the American Academy of Dermatology · 2023 · 1 citations
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