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GlossaryJAK3 Inhibitor

blocks an enzyme involved in immune response and inflammation

A JAK3 Inhibitor, also known as a Janus Kinase 3 Inhibitor, is a type of medication that blocks the activity of the JAK3 enzyme. This enzyme is involved in the signaling pathways that regulate immune responses and inflammation. By inhibiting JAK3, these drugs can help treat autoimmune diseases and conditions like alopecia areata, where the immune system mistakenly attacks hair follicles.

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research Inhibition of T-Cell Activity in Alopecia Areata: Recent Developments and New Directions

4 citations, November 2023 in “Frontiers in immunology”

New treatments targeting T-cell pathways are needed for better alopecia areata management.

research Use of Ritlecitinib for the Treatment of Alopecia Areata

December 2023 in “Journal of Ayub Medical College Abbottabad”

Ritlecitinib effectively treats alopecia areata in patients 12 and older with fewer side effects.

research Janus Kinase Inhibitors for Alopecia Areata: A Narrative Review

2 citations, June 2023 in “Indian journal of dermatology, venereology, and leprology”

Janus kinase inhibitors can regrow hair in alopecia areata but may cause side effects and hair loss may return if treatment stops.

research Janus Kinase Inhibitors for Alopecia Areata

7 citations, August 2023 in “Journal of the American Academy of Dermatology”

JAK inhibitors offer new hope for treating severe alopecia areata.

research Evolution of Ritlecitinib Population Pharmacokinetic Models During Clinical Drug Development

6 citations, November 2023 in “Clinical Pharmacokinetics”

Ritlecitinib shows promise as a versatile treatment for various autoimmune and inflammatory diseases.

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