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    Did you mean JAK3 Inhibitor?
    Glossary JAK3 Inhibitor

    blocks an enzyme involved in immune response and inflammation

    A JAK3 Inhibitor, also known as a Janus Kinase 3 Inhibitor, is a type of medication that blocks the activity of the JAK3 enzyme. This enzyme is involved in the signaling pathways that regulate immune responses and inflammation. By inhibiting JAK3, these drugs can help treat autoimmune diseases and conditions like alopecia areata, where the immune system mistakenly attacks hair follicles.

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    Research 30 of 530

    1. Efficacy and safety of ritlecitinib, an oral JAK3/TEC family kinase inhibitor, in adolescent and adult patients with alopecia totalis and alopecia universalis The Journal of Dermatology · 2024 · 7 citations
    2. Integrated Safety Analysis of Ritlecitinib, an Oral JAK3/TEC Family Kinase Inhibitor, for the Treatment of Alopecia Areata from the ALLEGRO Clinical Trial Program American journal of clinical dermatology · 2024
    3. 801 TEC family kinase inhibitors as a novel class of therapeutics in alopecia areata Journal of Investigative Dermatology · 2024
    4. 0935 Unravelling the role of JAK3/TEC kinase signalling with ritlecitinib in alopecia areata lesional skin and alopecia areata-induced human hair follicles ex vivo Journal of Investigative Dermatology · 2025
    5. 63418 JAK3/TEC kinase pathways are active in alopecia areata lesions, and their inhibition with Ritlecitinib prevents αCD3/αCD28+IL-2 induced immune privilege collapse in healthy hair follicles ex vivo Journal of the American Academy of Dermatology · 2025
    6. FDA approves Pfizer's JAK inhibitor for adolescents with alopecia areata hair loss Nature Medicine · 2023 · 4 citations
    7. Ritlecitinib in Alopecia Areata: A 24‐Week Real‐World Experience Contrasting JAK Inhibitor‐Naïve and JAK Inhibitor‐Experienced Patients The Journal of Dermatology · 2025
    8. Inhibition of T-cell activity in alopecia areata: recent developments and new directions Frontiers in immunology · 2023 · 4 citations
    9. 42004 Scalp, eyebrow, and eyelash hair regrowth with continued ritlecitinib treatment among patients with alopecia areata without target efficacy response at Week 24: post hoc analysis of the ALLEGRO phase 2b/3 study Journal of the American Academy of Dermatology · 2023 · 1 citations
    10. 42005 Sustained scalp, eyebrow, and eyelash hair regrowth with ritlecitinib through Week 48 in patients with alopecia areata: post hoc analysis of the ALLEGRO phase 2b/3 study Journal of the American Academy of Dermatology · 2023 · 1 citations
    11. Clinical Outcomes of Ritlecitinib in Treatment-Refractory Alopecia Areata: A Single-Center Real-World Study Skin Appendage Disorders · 2026
    12. A Cost-per-Responder Analysis of Ritlecitinib vs Baricitinib in Severe Alopecia Areata Journal of health economics and outcomes research · 2026
    13. Efficacy and Safety of Switching from Baricitinib to Ritlecitinib in Severe Alopecia Areata Clinical and Experimental Dermatology · 2024
    14. Advances in the mechanism and new therapies of alopecia areata International journal of rheumatic diseases · 2023
    15. Ritlecitinib: Efficacy of a Novel Therapy for Severe Alopecia Areata in Patients Aged 12 Years and Older Actas Dermo-Sifiliográficas · 2025
    16. Ritlecitinib Efficacy in Adolescents With Alopecia Areata: A Real‐World Experience International Journal of Dermatology · 2026
    17. Multiomics Analysis of the Response to Ritlecitinib in Alopecia Areata Subtypes and Correlation With Efficacy Allergy · 2025
    18. Alopecia areata and ritlecitinib: Unravelling response trajectories Journal of the European Academy of Dermatology and Venereology · 2025
    19. Integrated Safety Analysis of Ritlecitinib for the Treatment of Alopecia Areata (AA) From the Phase 2 and Phase 3 ALLEGRO Clinical Trial Program SKIN The Journal of Cutaneous Medicine · 2023 · 4 citations
    20. USE OF RITLECITINIB FOR THE TREATMENT OF ALOPECIA AREATA Journal of Ayub Medical College Abbottabad · 2023
    21. Efficacy and safety of ritlecitinib in adults and adolescents with alopecia areata: a randomised, double-blind, multicentre, phase 2b–3 trial The Lancet · 2023 · 227 citations
    22. Efficacy and safety of ritlecitinib in adolescents with alopecia areata: Results from the ALLEGRO phase 2b/3 randomized, double‐blind, placebo‐controlled trial Pediatric Dermatology · 2023 · 48 citations
    23. A Phase 1, Open‐Label Study of the Pharmacokinetics of Ritlecitinib in Children Aged 6–12 Years With Alopecia Areata Pediatric Dermatology · 2025 · 5 citations
    24. Moving Beyond Boundaries: Utilization of Longitudinal Exposure–Response Model for Bounded Outcome Score to Inform Decision Making in the Accelerated Drug Development Paradigm Clinical Pharmacokinetics · 2024 · 5 citations
    25. SALT score distribution with ritlecitinib treatment up to 24 months in alopecia areata Journal of the European Academy of Dermatology and Venereology · 2025 · 2 citations
    26. Ritlecitinib for the Management of Alopecia Areata: A Narrative Review of Real-World Evidence and Selected Post Hoc Analyses Dermato · 2026 · 1 citations
    27. Real-World Ritlecitinib Treatment of Severe Alopecia Areata (AA) in the US: Patient Characteristics and Physician Satisfaction SKIN The Journal of Cutaneous Medicine · 2025
    28. Efficacy of Ritlecitinib in Patients with Alopecia Areata by Extent of Hair Loss: Results from the Phase 2b/3 and Phase 3 ALLEGRO Clinical Trials SKIN The Journal of Cutaneous Medicine · 2024
    29. Distribution of SALT Scores with Ritlecitinib Treatment up to 24 months from the ALLEGRO Phase 2b/3 and Long-Term Phase 3 Clinical Studies in Alopecia Areata SKIN The Journal of Cutaneous Medicine · 2024
    30. Sustained Scalp, Eyebrow, and Eyelash Hair Regrowth with Ritlecitinib Through Week 48 in Patients with Alopecia Areata: Post-Hoc Analysis of the ALLEGRO Phase 2b/3 Study SKIN The Journal of Cutaneous Medicine · 2023