Local Heroes or Villains: Tissue-Resident Memory T Cells in Human Health and Disease

The document discussed the dual role of tissue-resident memory T (TRM) cells in human health and disease, highlighting their protective function against infections and cancer, as well as their harmful involvement in autoimmune skin diseases like psoriasis, alopecia areata, and vitiligo. It summarized the biology of TRM cells based on animal models and human studies, emphasizing the need for a deeper understanding of TRM cell mechanisms. This knowledge is crucial for developing safe therapeutic strategies that can boost protective immune responses without causing tissue damage and eliminate pathogenic TRM cells without compromising local immunity.