Mesenchymal Stem Cell-Derived Extracellular Vesicles and Plant-Derived Nanovesicles as Cell-Free Therapies for Thermal Burn Healing: A Systematic Review of Preclinical Evidence and Delivery Strategies

    May 2026 in “ Medical Sciences ”
    Alexandru Hristo Amarandei, Stefana Avadanei-Luca, Andra-Irina Bulgaru-Iliescu … Mihaela Perțea
    Studysummary This review found that vesicle-based therapies, including mammalian MSC-derived and plant-derived vesicles, consistently promote wound healing in preclinical models of thermal injury and may offer a safer alternative to live cell transplants.
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    Research cited in this study 7

    1. Stem Cell-Derived and Plant-Derived Exosomes: Promising Therapeutics for Skin Healing and Regeneration Molecular and Cellular Probes · 2026
    2. Traditional Chinese Medicine Derived Exosome-Like Nanovesicles in Wound Repair and Skin Regeneration Frontiers in Cell and Developmental Biology · 2025
    3. Exosome Laden Sprayable Thermo-Sensitive Polysaccharide-Based Hydrogel for Enhanced Burn Wound Healing International Journal of Biological Macromolecules · 2024
    4. Exosomes Derived From Mouse Vibrissa Dermal Papilla Cells Promote Hair Follicle Regeneration During Wound Healing By Activating Wnt/β-Catenin Signaling Pathway Journal of Nanobiotechnology · 2024
    5. Exosomes: A Promising Strategy for Repair, Regeneration and Treatment of Skin Disorders Cells · 2023
    6. Hair Follicle Mesenchymal Stem Cell Exosomal LncRNA H19 Inhibited NLRP3 Pyroptosis to Promote Diabetic Mouse Skin Wound Healing Aging · 2023
    7. Potential of Colostrum-Derived Exosomes for Promoting Hair Regeneration Through the Transition from Telogen to Anagen Phase Frontiers in Cell and Developmental Biology · 2022