Traditional Chinese Medicine Derived Exosome-Like Nanovesicles in Wound Repair and Skin Regeneration

    September 2025 in “ Frontiers in Cell and Developmental Biology ”
    Kang Wang, Zhongneng Yang, Fei Wang, Yong Ma, Yong Qing, Zhenyu Zhang
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    Studysummary This review highlights that exosome-like nanovesicles derived from traditional Chinese medicinal herbs show potential in enhancing wound healing processes such as inflammation resolution and angiogenesis, suggesting promising applications in skin regeneration and therapeutic development.
    Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
    The document reviews the potential of traditional Chinese medicine-derived exosome-like nanovesicles (TCM-ELNVs) in wound repair and skin regeneration. TCM-ELNVs offer advantages over mammalian exosomes, such as better bioavailability, scalable production, and reduced zoonotic risks. They are rich in bioactive compounds, contributing to their anti-inflammatory, antioxidant, and wound-healing properties. The review highlights the processes of isolating, characterizing, and delivering TCM-ELNVs, emphasizing their stability and bioactivity. Despite their promise, the application of TCM-ELNVs in skin healing is still in early stages, with ongoing research needed to fully understand their mechanisms and optimize their therapeutic use.
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