Garlic Exosomes Promote Hair Growth Through the Wnt/Beta-Catenin Pathway and Growth Factors

    July 2023 in “ Cureus
    Esma Yüksel, Demet Cicek, Betül Demir, Kazim Sahin, Mehmet Tuzcu, Cemal Orhan, Ibrahim Hanifi Ozercan, Fikrettin Sahin, Pelin Kocak, Merve Yildirim
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    TLDR Garlic can help hair grow by activating certain growth pathways, and it works whether you eat it or apply it to your scalp.
    The study conducted on 42 rats demonstrated that both oral and topical applications of Garlic Exosomes (GEs) significantly promoted hair growth by activating Wnt-1, β-catenin, VEGF, PDGF, and TGF-β1 signaling pathways. The number of anagen follicles (active growth phase of hair follicles) increased even at a low dose of GEs (2 mg/kg/day). A higher dose (4 mg/kg/day) resulted in larger follicle diameter and more pronounced activation of signaling pathways. Topical application of GEs not only increased anagen follicle growth equivalent to the low-dose oral GE but also increased the follicle diameter more than the low-dose oral GE, and stimulated the β-catenin, VEGF, PDGF, and TGF-β1 pathways to a greater extent. The study suggests GEs could potentially be used for treating hair loss in humans, pending further research.
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