Exosome Laden Sprayable Thermo-Sensitive Polysaccharide-Based Hydrogel for Enhanced Burn Wound Healing
December 2024
in “
International Journal of Biological Macromolecules
”
New to Exosomes? There is a guide in the encyclopedia. Read the guide → Studysummary This study introduced a novel exosome-loaded sprayable hydrogel (ADA-aPF127@LL18/Exo) that significantly enhanced wound healing in a deep partial thickness burn model, showing improved antibacterial efficacy and promoting tissue recovery processes like epithelialization and hair follicle regeneration.
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The study presents a novel sprayable thermo-sensitive polysaccharide-based hydrogel (ADA-aPF127@LL18/Exo) designed to enhance burn wound healing. This hydrogel, which includes alginate dialdehyde and aminated Pluronic F127, offers sustained release of exosomes and improved antibacterial properties due to the inclusion of the antimicrobial peptide LL18. The hydrogel demonstrated excellent biocompatibility, promoting cell proliferation and migration in vitro. In a rat model of deep partial thickness burns, the hydrogel significantly improved wound healing by accelerating epithelialization, promoting granulation tissue formation, collagen deposition, hair follicle regeneration, reducing inflammation, and enhancing neovascularization. This innovative dressing shows promise as an effective treatment for deep burns, offering easy application and maintaining a moist wound environment.
