Autologous Micrografts Containing Nanovesicles, Exosomes, and Follicle Stem Cells in Androgenetic Alopecia: In Vitro and In Vivo Analysis Through a Multicentric, Observational, Evaluator-Blinded Study

October 2024 in “ Aesthetic Plastic Surgery ”

Pietro Gentile, Simone Garcovich, Franco Perego, Nazneen Arsiwala, Mahmut Yavuz, Valeria Pessei, Tommaso Pusceddu, Barbara Zavan, S Arsiwala

autologous micrografts nanovesicles exosomes follicle stem cells androgenetic alopecia human follicle mesenchymal stem cells extracellular vesicles hair density pattern hair loss hair loss stem cell therapy

Studysummary In this multicenter observational study, researchers found that using micrografts with human follicle mesenchymal stem cells increased hair density significantly in both male and female patients with mild to moderate androgenic alopecia after 12 months, suggesting a viable alternative for hair regrowth. Our plain-language summary of this paper — not a Tressless recommendation.

The study explores the effectiveness of autologous micrografts containing human follicle mesenchymal stem cells, exosomes, and extracellular vesicles for treating androgenetic alopecia. Conducted with 60 patients (40 males and 20 females) experiencing mild to moderate hair loss, the multicentric, observational, evaluator-blinded study found a significant increase in hair density after 12 months. Females showed an increase of 28 ± 4 hairs/cm², while males had an increase of 30 ± 5 hairs/cm² in the targeted area. The study concludes that these micrografts are a safe and effective alternative treatment for both male and female pattern hair loss.

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