Rose Stem Cell-Derived Exosomes for Hair Regeneration Enhancement via Noninvasive Electroporation in Androgenetic Alopecia

This study explores the use of rose stem cell-derived exosomes (RSCEs) for hair regeneration in a 54-year-old male with androgenetic alopecia (AGA) via noninvasive electroporation. The patient underwent 12 sessions of RSCE treatment, resulting in significant hair density and thickness improvements without serious adverse events. RSCEs were found to activate the Wnt/ß-catenin signaling pathway, promoting dermal papilla cell proliferation and reducing inflammation. Despite promising results, the study's single-case sample size and lack of a control group limit its generalizability. Future research should include larger, randomized controlled trials to validate these findings and explore long-term effects and cost-effectiveness.