Analysis of LncRNA and mRNA Expression Profiles in Skin Tissues of Super Merino Sheep and Small-Tailed Han Sheep

November 2023

Jiaqi Fu, Anqi Hao, X. Zhang, Wei Wang, Wenqing Liu, Caihong Zhang, Dongfeng Zhao, Zhenghua Zhao, Lichun Zhang, Feng-Yan Sun

TLDR Researchers found genes in sheep that may affect hair growth and wool quality.

The study analyzed the skin tissues of Super Merino (SM) and Small-Tailed Han (STH) sheep to identify differentially expressed long non-coding RNAs (lncRNAs) and messenger RNAs (mRNAs) using histopathological observation and high-throughput RNA sequencing. Significant differences were found in the expression levels of several genes, including LOC114113396 (KRTAP15-1), CRABP1, KRT10, KRTAP1-3, KRTAP4.3, KRT2, FGF1, IGF-1, and KIT, which are important for hair follicle growth and hair fiber traits. The study also identified lncRNAs that may indirectly influence hair follicle development and hair fiber diameter by regulating target gene expression. These findings provide a basis for further research on sheep hair follicle growth and hair fiber characteristics.

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