Analysis of LncRNA and mRNA Expression Profiles in Skin Tissues of Super Merino Sheep and Small-Tailed Han Sheep
November 2023
hair follicle growth hair fiber characteristics long non-coding RNAs lncRNAs messenger RNAs mRNAs Gene Ontology GO Kyoto Encyclopedia of Genes and Genomes KEGG Reverse transcription quantitative Polymerase Chain Reaction RT-qPCR LOC114113396 CRABP1 IGF-1 hair growth hair characteristics non-coding RNAs gene ontology insulin-like growth factor 1
TLDR Researchers found genes in sheep that may affect hair growth and wool quality.
The study analyzed the skin tissues of Super Merino (SM) and Small-Tailed Han (STH) sheep to identify differentially expressed long non-coding RNAs (lncRNAs) and messenger RNAs (mRNAs) using histopathological observation and high-throughput RNA sequencing. Significant differences were found in the expression levels of several genes, including LOC114113396 (KRTAP15-1), CRABP1, KRT10, KRTAP1-3, KRTAP4.3, KRT2, FGF1, IGF-1, and KIT, which are important for hair follicle growth and hair fiber traits. The study also identified lncRNAs that may indirectly influence hair follicle development and hair fiber diameter by regulating target gene expression. These findings provide a basis for further research on sheep hair follicle growth and hair fiber characteristics.
