Selective Delivery of Tofacitinib Citrate to Hair Follicles Using Lipid-Coated Calcium Carbonate Nanocarriers Controls Chemotherapy-Induced Alopecia Areata

    May 2023 in “ International Journal of Molecular Sciences ”
    Yeneng Guan, Aqin Yan, Qiang Wang … Hongda Zhu
    Studysummary In this study, researchers observed that phospholipid-calcium carbonate hybrid nanoparticles effectively delivered Tofacitinib citrate topically, which significantly inhibited hair follicle apoptosis and promoted hair growth in a mouse model of chemotherapy-induced alopecia, compared to a traditional Tofacitinib solution.
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    Research cited in this study 22

    1. Minoxidil-Loaded Hyaluronic Acid Dissolving Microneedles to Alleviate Hair Loss in an Alopecia Animal Model Acta Biomaterialia · 2022
    2. Clinicopathologic Characteristics and Response to Treatment of Persistent Chemotherapy-Induced Alopecia in Breast Cancer Survivors JAMA Dermatology · 2021
    3. Selective Inhibition of JAK3 Signaling Is Sufficient to Reverse Alopecia Areata JCI insight · 2021
    4. Tofacitinib Loaded Squalenyl Nanoparticles for Targeted Follicular Delivery in Inflammatory Skin Diseases Pharmaceutics · 2020
    5. Hair Follicle Targeting With Curcumin Nanocrystals: Influence of Formulation Properties on Penetration Efficacy Journal of Controlled Release · 2020
    6. Determination of the pH Gradient in Hair Follicles of Human Volunteers Using pH-Sensitive Melamine Formaldehyde-Pyranine Nile Blue Microparticles Sensors · 2020
    7. The Effect of JAK Inhibitor on Survival, Anagen Re-Entry, and Hair Follicle Immune Privilege Restoration in Human Dermal Papilla Cells International Journal of Molecular Sciences · 2020
    8. New and Emerging Therapies for Alopecia Areata Drugs · 2020
    9. Benefit and Risk Profile of Tofacitinib for the Treatment of Alopecia Areata: A Systematic Review and Meta-Analysis Journal of the European Academy of Dermatology and Venereology · 2019
    10. Genetic Analysis of a Novel Antioxidant Multi-Target Iron Chelator, M30, Protecting Against Chemotherapy-Induced Alopecia in Mice BMC cancer · 2019
    11. Janus Kinase Inhibitors for the Treatment of Severe Alopecia Areata: An Open-Label Comparative Study Dermatology · 2018
    12. Effects of Mesenchymal Stem Cell Therapy on Alopecia Areata in Cellular and Hair Follicle Organ Culture Models Experimental Dermatology · 2018
    13. Selective Delivery of Adapalene to the Human Hair Follicle Under Finite Dose Conditions Using Polymeric Micelle Nanocarriers Nanoscale · 2017
    14. Alopecia Areata: Overview and Insights from January 2018 Journal of The American Academy of Dermatology · 2017
    15. Synthesis and Validation of Functional Nanogels as pH-Sensors in the Hair Follicle Macromolecular bioscience · 2017
    16. Preventive Effects of Cedrol Against Alopecia in Cyclophosphamide-Treated Mice Environmental Toxicology and Pharmacology · 2016
    17. Inhibitory Activities of Some Traditional Chinese Herbs Against Testosterone 5α-Reductase and Effects of Cacumen Platycladi on Hair Regrowth in Testosterone-Treated Mice Journal of Ethnopharmacology · 2015
    18. Alopecia Areata Is Driven by Cytotoxic T Lymphocytes and Is Reversed by JAK Inhibition Nature medicine · 2014
    19. Squarticles as a Lipid Nanocarrier for Delivering Diphencyprone and Minoxidil to Hair Follicles and Human Dermal Papilla Cells Aaps Journal · 2013
    20. Triggering of Drug Release of Particles in Hair Follicles Journal of controlled release · 2012
    21. Calcitonin Gene-Related Peptide (CGRP) May Award Relative Protection from Interferon-γ-Induced Collapse of Human Hair Follicle Immune Privilege Experimental Dermatology · 2011
    22. A Guide to Assessing Damage Response Pathways of the Hair Follicle: Lessons From Cyclophosphamide-Induced Alopecia in Mice Journal of Investigative Dermatology · 2005

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