Selective Delivery of Tofacitinib Citrate to Hair Follicles Using Lipid-Coated Calcium Carbonate Nanocarriers Controls Chemotherapy-Induced Alopecia Areata

May 2023 in “ International Journal of Molecular Sciences ”

Yeneng Guan, Aqin Yan, Qiang Wang, Rui Ruan, Chaobo Yang, Kai Ma, Hongmei Sun, Mingxing Liu, Hongda Zhu

Tofacitinib Citrate lipid-coated calcium carbonate nanoparticles chemotherapy-induced alopecia areata alopecia areata PL/ACC NPs Cyclophosphamide hair follicles pH sensitivity transdermal penetration MHC molecules Tofacitinib chemotherapy-induced hair loss AA PL/ACC-TFC NPs CYP hair growth immune molecules

TLDR A new treatment using nanoparticles can effectively prevent and reduce hair loss caused by chemotherapy.

The study presents a novel approach to treating chemotherapy-induced alopecia areata (AA) using lipid-coated calcium carbonate nanoparticles (PL/ACC NPs) to deliver Tofacitinib Citrate (TFC) directly to hair follicles. The PL/ACC-TFC NPs showed excellent pH sensitivity and transdermal penetration in vitro. In a Cyclophosphamide (CYP)-induced AA mouse model, these nanoparticles significantly promoted hair growth and alleviated AA more effectively than the TFC solution group. The study also found that TFC reduced the secretion of ectopic MHC molecules, which are overexpressed in AA. However, TFC's protective effect on hair follicles might be greater than its repair effect. The study concludes that PL/ACC-TFC NPs have potential for use in the prevention and mitigation of CYP-induced AA.

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18 / 18 results

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