Selective Delivery of Tofacitinib Citrate to Hair Follicles Using Lipid-Coated Calcium Carbonate Nanocarriers Controls Chemotherapy-Induced Alopecia Areata

    Yeneng Guan, Aqin Yan, Qiang Wang, Rui Ruan, Chaobo Yang, Kai Ma, Hongmei Sun, Mingxing Liu, Hongda Zhu
    Image of study
    TLDR A new treatment using nanoparticles can effectively prevent and reduce hair loss caused by chemotherapy.
    The study presents a novel approach to treating chemotherapy-induced alopecia areata (AA) using lipid-coated calcium carbonate nanoparticles (PL/ACC NPs) to deliver Tofacitinib Citrate (TFC) directly to hair follicles. The PL/ACC-TFC NPs showed excellent pH sensitivity and transdermal penetration in vitro. In a Cyclophosphamide (CYP)-induced AA mouse model, these nanoparticles significantly promoted hair growth and alleviated AA more effectively than the TFC solution group. The study also found that TFC reduced the secretion of ectopic MHC molecules, which are overexpressed in AA. However, TFC's protective effect on hair follicles might be greater than its repair effect. The study concludes that PL/ACC-TFC NPs have potential for use in the prevention and mitigation of CYP-induced AA.
    Discuss this study in the Community →

    Research cited in this study

    22 / 22 results

    Related Community Posts Join

    6 / 15 results

      community Anyone with LPP have regrowth with Xeljanz?

      in Treatment  3 upvotes 1 year ago
      The conversation is about using Xeljanz for hair regrowth in individuals with LPP. The user is seeking experiences and expectations from others who have tried this treatment.

      community IGE Hair Loss and Miniaturization

      in Chat  3 upvotes 11 months ago
      A 23-year-old male is experiencing diffuse hair loss and miniaturization, possibly due to high IGE levels after using tofacitinib. He seeks advice and has not yet consulted a dermatologist.

      community Topical solution recommendation

      in Treatment  2 upvotes 7 months ago
      The user is using finasteride 1mg every other day and seeks a topical solution excluding minoxidil. They are considering various combinations of ingredients like finasteride, dutasteride, and tofacitinib, with options for nourishing oils and other additives.

      community No hair, don't care! [24/F] :)

       60 upvotes 10 years ago
      A woman with alopecia universalis shares her positive experience of being bald, finding it freeing and less worrisome. She also discusses her skincare routine using Korean products.

      community Alopecia Areata Question

      in Treatment  2 upvotes 5 years ago
      A user with alopecia totalis, borderline universalis, seeks advice on getting into a Xeljanz trial or appealing insurance for coverage. They experienced significant hair regrowth but are now seeing hair loss again and want to try Xeljanz.

      community Xeljanz....the magic drug!!!

       2 upvotes 7 years ago
      A user experienced significant hair regrowth from Xeljanz after severe alopecia but can no longer afford it. They are seeking ways to obtain the medication despite its high cost and potential side effects.

    Related Research

    5 / 5 results