New and Emerging Therapies for Alopecia Areata

    April 2020 in “ Drugs ”
    Aunna Pourang, Natasha Atanaskova Mesinkovska
    Studysummary Emerging therapies like JAK inhibitors show promise for hair regrowth in alopecia areata.
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    Research cited in this study 61

    1. Meta-Analysis of Photobiomodulation for the Treatment of Androgenetic Alopecia Journal of Dermatological Treatment · 2019
    2. Alopecia Areata in 2 Patients Treated with Dupilumab: New Onset and Worsening JAAD Case Reports · 2019
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    4. Cyclosporine for Moderate-to-Severe Alopecia Areata: A Double-Blind, Randomized, Placebo-Controlled Clinical Trial of Efficacy and Safety Journal of the American Academy of Dermatology · 2019
    5. Scalp Bacterial Shift in Alopecia Areata PloS one · 2019
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    7. Dupilumab Improved Alopecia Areata in a Patient with Atopic Dermatitis: A Case Report Acta Dermato Venereologica · 2019
    8. Vitamin D and Alopecia Areata: Possible Roles in Pathogenesis and Potential Implications for Therapy PubMed · 2019
    9. Janus Kinase Inhibitors for the Treatment of Severe Alopecia Areata: An Open-Label Comparative Study Dermatology · 2018
    10. A Randomized Placebo-Controlled Single-Center Pilot Study of the Safety and Efficacy of Apremilast in Subjects with Moderate-to-Severe Alopecia Areata Archives of dermatological research · 2018
    11. Effects of Mesenchymal Stem Cell Therapy on Alopecia Areata in Cellular and Hair Follicle Organ Culture Models Experimental Dermatology · 2018
    12. Response to Ustekinumab in Three Pediatric Patients with Alopecia Areata Pediatric dermatology · 2018
    13. Treatment of Alopecia Universalis with Topical Janus Kinase Inhibitors – A Double Blind, Placebo, and Active Controlled Pilot Study International Journal of Dermatology · 2018
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    15. Alopecia Areata and the Gut: The Link Opens Up for Novel Therapeutic Interventions Expert Opinion on Therapeutic Targets · 2018
    16. Cellular Therapy with Human Autologous Adipose-Derived Adult Cells of Stromal Vascular Fraction for Alopecia Areata Stem Cell Research & Therapy · 2018
    17. Retrospective Analysis of the Application of Fumaric Acid Esters in 13 Patients with Alopecia Areata European journal of dermatology/EJD. European journal of dermatology · 2018
    18. Nail Involvement in Patients with Moderate-to-Severe Alopecia Areata Treated with Oral Tofacitinib Journal of Dermatological Treatment · 2018
    19. An Open-Label Pilot Study to Evaluate the Efficacy of Tofacitinib in Moderate to Severe Patch-Type Alopecia Areata, Totalis, and Universalis Journal of Investigative Dermatology · 2018
    20. Vitamin D Deficiency in Patients With Alopecia Areata: A Systematic Review and Meta-Analysis Journal of the American Academy of Dermatology · 2017
    21. Tofacitinib 2% Ointment, a Topical Janus Kinase Inhibitor, for the Treatment of Alopecia Areata: A Pilot Study of 10 Patients Journal of the American Academy of Dermatology · 2017
    22. Oral Tofacitinib Monotherapy in Korean Patients with Refractory Moderate-to-Severe Alopecia Areata: A Case Series Journal of the American Academy of Dermatology · 2017
    23. Efficacy of Topical Tofacitinib in Promoting Hair Growth in Non-Scarring Alopecia: Possible Mechanism via VEGF Induction Archives of Dermatological Research · 2017
    24. The Changing Landscape of Alopecia Areata: The Therapeutic Paradigm Advances in Therapy · 2017
    25. Management of Alopecia Areata: Updates and Algorithmic Approach Journal of dermatology · 2017
    26. Treatment of Alopecia Areata With Tofacitinib JAMA Dermatology · 2017
    27. Efficacy and Safety of Topical Calcipotriol in Management of Alopecia Areata: A Pilot Study Dermatologic Therapy · 2017
    28. Simvastatin/Ezetimibe Therapy for Recalcitrant Alopecia Areata: An Open Prospective Study of 14 Patients Annals of dermatology/Annals of Dermatology · 2017
    29. Use of Lasers in the Treatment of Alopecia Areata Medical lasers · 2016
    30. Tofacitinib for the Treatment of Alopecia Areata and Variants in Adolescents Journal of the American Academy of Dermatology · 2016
    31. Tofacitinib for the Treatment of Severe Alopecia Areata and Variants: A Study of 90 Patients Journal of The American Academy of Dermatology · 2016
    32. Platelet-Rich Plasma Versus Minoxidil 5% in Treatment of Alopecia Areata: A Trichoscopic Evaluation Dermatologic Therapy · 2016
    33. Safety and Efficacy of the JAK Inhibitor Tofacitinib Citrate in Patients with Alopecia Areata JCI insight · 2016
    34. Oral Ruxolitinib Induces Hair Regrowth in Patients with Moderate-to-Severe Alopecia Areata JCI insight · 2016
    35. Extensive Alopecia Areata Is Reversed by IL-12/IL-23p40 Cytokine Antagonism The Journal of Allergy and Clinical Immunology · 2015
    36. Therapy for Alopecia Areata in Mice by Stimulating the Hair Cycle with Parathyroid Hormone Agonists Linked to a Collagen-Binding Domain Journal of Investigative Dermatology Symposium Proceedings · 2015
    37. Clinical Efficacy of Diphenylcyclopropenone in Alopecia Areata: Retrospective Data Analysis of 50 Patients ˜The œjournal of investigative dermatology. Symposium proceedings/˜The œJournal of investigative dermatology symposium proceedings · 2015
    38. Pharmacologic Inhibition of JAK-STAT Signaling Promotes Hair Growth Science Advances · 2015
    39. Alopecia Areata Profiling Shows TH1, TH2, and IL-23 Cytokine Activation Without Parallel TH17/TH22 Skewing ˆThe ‰journal of allergy and clinical immunology/Journal of allergy and clinical immunology/˜The œjournal of allergy and clinical immunology · 2015
    40. Epidemiology and Burden of Alopecia Areata: A Systematic Review Clinical, Cosmetic and Investigational Dermatology · 2015
    41. Topical Calcipotriol Therapy for Mild-to-Moderate Alopecia Areata: A Retrospective Study PubMed · 2015
    42. Reversal of Alopecia Areata Following Treatment With the JAK1/2 Inhibitor Baricitinib EBioMedicine · 2015
    43. Alopecia Areata Is Driven by Cytotoxic T Lymphocytes and Is Reversed by JAK Inhibition Nature medicine · 2014
    44. Potential Relationship Between the Canonical Wnt Signaling Pathway and Expression of the Vitamin D Receptor in Alopecia Clinical and experimental dermatology · 2014
    45. Limited Effectiveness of Platelet-Rich Plasma Treatment on Chronic Severe Alopecia Areata Hair therapy & transplantation · 2014
    46. The Effect of Oral Cyclosporine in the Treatment of Severe Alopecia Areata Cutaneous and ocular toxicology · 2013
    47. Successful Treatment of Alopecia Totalis with Hydroxychloroquine: Report of 2 Cases Journal of the American Academy of Dermatology · 2013
    48. A Randomized, Double-Blind, Placebo- and Active-Controlled, Half-Head Study to Evaluate the Effects of Platelet-Rich Plasma on Alopecia Areata British Journal of Dermatology · 2013
    49. Case of Intractable Ophiasis Type of Alopecia Areata Presumably Improved by Fexofenadine The Journal of Dermatology · 2012
    50. Autologous Platelet-Rich Plasma: A Potential Therapeutic Tool for Promoting Hair Growth Dermatologic Surgery · 2012
    51. Dihydrotestosterone-Inducible IL-6 Inhibits Elongation of Human Hair Shafts by Suppressing Matrix Cell Proliferation and Promotes Regression of Hair Follicles in Mice Journal of Investigative Dermatology · 2011
    52. Intralesional Steroids for Alopecia Areata International Journal of Trichology · 2010
    53. Two Cases of Alopecia Areata Responsive to Fexofenadine The Journal of Dermatology · 2007
    54. Minoxidil: Mechanisms of Action on Hair Growth British Journal of Dermatology · 2004
    55. Restoration of Hair Growth in Mice with an Alopecia Areata-Like Disease Using Topical Anthralin Experimental Dermatology · 2004
    56. Clobetasol Propionate 0.05% Under Occlusion in the Treatment of Alopecia Totalis/Universalis Journal of the American Academy of Dermatology · 2003
    57. Gene Array Profiling and Immunomodulation Studies Define a Cell-Mediated Immune Response Underlying the Pathogenesis of Alopecia Areata in a Mouse Model and Humans Journal of Investigative Dermatology · 2002
    58. Efficacy of Topical Sensitizers in the Treatment of Alopecia Areata Journal of the American Academy of Dermatology · 1998
    59. Interleukin 6: Insights Into Its Function in Skin by Overexpression in Transgenic Mice Proceedings of the National Academy of Sciences · 1992
    60. Topical Photochemotherapy for Alopecia Areata Journal of the American Academy of Dermatology · 1985
    61. Topical Minoxidil in the Treatment of Alopecia Areata BMJ · 1983

    Related research 3

    1. Alopecia Areata: A Multifactorial Autoimmune Condition Journal of autoimmunity · 2018
    2. Linear Alopecia Areata JAAD case reports · 2018
    3. Treating Resistant Cases of Alopecia Universalis Journal of cosmetology & trichology · 2018