Heat Treatment Increases the Incidence of Alopecia Areata in the C3H/HeJ Mouse Model

June 2010 in “ Cell Stress and Chaperones ”

Tongyu C. Wikramanayake, Elizabeth Alvarez‐Connelly, Jessica Simon, Lucía Mercedes Mauro, Javier Z. Guzman, George W. Elgart, Lawrence A. Schachner, Juan Chen, Lisa R. W. Plano, Joaquín J. Jiménez

alopecia areata C3H/HeJ mouse model heat treatment anagen hair follicles HSPA1A/B mononuclear cell infiltration AA heat stress hair loss

TLDR Heat treatment increases hair loss in certain mice.

The study demonstrated that heat treatment significantly increased the incidence of alopecia areata (AA) in C3H/HeJ mice, with 23% of heat-treated mice developing AA compared to 7.5% of sham-treated mice. This effect was observed at an earlier age of 8 months, rather than the usual 18 months. Histological analysis confirmed AA characteristics, and increased expression of the stress-induced protein HSPA1A/B was noted in heat-treated mice. These findings suggested that heat-induced stress could trigger AA in genetically susceptible mice, providing a useful model for studying stress responses in AA and indicating a potential link between stress-induced proteins and autoimmune responses.

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Research cited in this study

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