Heat Treatment Increases the Incidence of Alopecia Areata in the C3H/HeJ Mouse Model

June 2010 in “ Cell Stress and Chaperones ”

Tongyu C. Wikramanayake, Elizabeth Alvarez‐Connelly, Jessica Simon, Lucía Mercedes Mauro, Javier Z. Guzman, George W. Elgart, Lawrence A. Schachner, Juan Chen, Lisa R. W. Plano, Joaquín J. Jiménez

alopecia areata C3H/HeJ mouse model heat treatment anagen hair follicles HSPA1A/B mononuclear cell infiltration AA heat stress hair loss

TLDR Heat treatment increases hair loss in certain mice.

This study investigated the impact of heat treatment, a form of physiological stress, on the development of alopecia areata (AA) in C3H/HeJ mice, which are predisposed to AA. The researchers found that heat-treated 8-month-old C3H/HeJ mice showed a significant increase in hair loss compared to sham-treated mice. Histological analysis revealed mononuclear cell infiltration in anagen hair follicles, a hallmark of AA, in the heat-treated mice. Additionally, there was increased expression of HSPA1A/B in the skin of heat-treated mice, which was also observed in mice that developed AA spontaneously. These findings suggested that the induction of HSPA1A/B might trigger AA development in this mouse model, indicating that heat-treated C3H/HeJ mice could serve as a valuable model for studying stress responses in AA.

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Research cited in this study

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