TLDR Gonadal hormones significantly affect the severity of alopecia areata in mice.
The study investigated the role of gonadal steroid hormones and hair follicle melanocytes in modifying the severity of alopecia areata (AA) in C3H/HeJ mice. Gonadectomized mice showed a 2-4 week delay in AA onset compared to controls, with some not developing AA at all. Estradiol supplementation in females led to rapid AA progression, while dihydrotestosterone in males increased resistance to AA. Additionally, both pigmented and non-pigmented hair in these mice were susceptible to AA. The findings indicated that gonadal hormones significantly influenced AA severity, highlighting the complex interplay of genetic and epigenetic factors in AA susceptibility.
32 citations,
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131 citations,
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8 citations,
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154 citations,
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17 citations,
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148 citations,
December 2018 in “Journal of autoimmunity” Alopecia areata is an autoimmune disease causing patchy hair loss, often with other autoimmune disorders, but its exact causes are unknown.
4 citations,
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