Comparison of Efficacy of Autologous Platelet Rich Plasma Therapy With 5% Topical Minoxidil Spray in Treating Alopecia Areata: A Head-to-Head Assessment of Novel Approaches

The study compared the efficacy of autologous platelet-rich plasma (PRP) therapy and 5% topical minoxidil spray in treating alopecia areata over four months with 40 patients (31 males, 9 females). Both treatments showed similar effects initially, but PRP therapy demonstrated a significantly greater reduction in the Severity of Alopecia Tool (SALT) score at two months (p=0.037) and a highly significant difference at four months (p<0.0001). The conclusion is that monthly intralesional PRP therapy is more effective than daily topical minoxidil in managing alopecia areata.