Platelet-Rich Plasma in Alopecia Areata and Primary Cicatricial Alopecias: A Systematic Review

    November 2022 in “ Frontiers in Medicine ”
    Kasama Tejapira, Tanat Yongpisarn, Nawara Sakpuwadol, Poonkiat Suchonwanit
    TLDR PRP shows promise for treating mild alopecia areata but needs more research for cicatricial alopecias.
    This systematic review assessed the efficacy of platelet-rich plasma (PRP) in treating alopecia areata (AA) and primary cicatricial alopecias (PCAs) by analyzing 32 studies with 621 AA patients and 19 PCA patients. PRP showed promising results in AA, especially in mild cases, with better efficacy than placebo and similar efficacy to intralesional triamcinolone acetonide (TA). PRP also had benefits as an adjunctive treatment. However, its efficacy in PCAs was less clear due to limited studies and variable responses. The review emphasizes the need for more high-quality, randomized controlled trials to confirm PRP's therapeutic potential in these conditions.
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