Reversible Hair Loss in Lichen Planopilaris: Regrowth With Low-Dose Naltrexone and Platelet-Rich Plasma

    Elizabeth G. Klein, Maria Karim, Randie H. Kim, Kristen Lo Sicco, Jerry Shapiro
    From the encyclopedia
    Platelet-Rich Plasma →

    growth factors taken from your blood and injected into your scalp to stimulate hair

    Finasteride →

    Frontline, gold standard treatment for combatting androgenic alopecia

    Minoxidil →

    An essential vasodilator with some anti-androgenic effects

    Studysummary This case report describes a patient with lichen planopilaris who experienced remarkable hair regrowth at a previously scarred area after treatment with low-dose naltrexone and platelet-rich plasma, following minimal response to other therapies.
    Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
    A 46-year-old woman with biopsy-confirmed lichen planopilaris (LPP) experienced significant hair regrowth in a previously scarred alopecic patch after treatment with low-dose naltrexone (LDN) and platelet-rich plasma (PRP). This occurred despite minimal response to prior therapies, including intralesional corticosteroids, topical clobetasol, topical minoxidil, finasteride, doxycycline, and ketoconazole shampoo. This case underscores the potential of LDN and PRP as effective treatments for LPP and highlights the need for more comprehensive research on treatment options and prognosis for LPP patients.
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