Reversible Hair Loss in Lichen Planopilaris: Regrowth With Low-Dose Naltrexone and Platelet-Rich Plasma

    May 2022 in “ Journal of Drugs in Dermatology ”
    Elizabeth G. Klein, Maria Karim, Randie H. Kim, Kristen Lo Sicco, Jerry Shapiro
    TLDR Low-dose naltrexone and platelet-rich plasma can regrow hair in lichen planopilaris.
    A 46-year-old woman with biopsy-confirmed lichen planopilaris (LPP) experienced significant hair regrowth in a previously scarred alopecic patch after treatment with low-dose naltrexone (LDN) and platelet-rich plasma (PRP). This occurred despite minimal response to prior therapies, including intralesional corticosteroids, topical clobetasol, topical minoxidil, finasteride, doxycycline, and ketoconazole shampoo. This case underscores the potential of LDN and PRP as effective treatments for LPP and highlights the need for more comprehensive research on treatment options and prognosis for LPP patients.
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      community The Worst Hair Loss Condition You (MAY) have: LPP

      in Research/Science  43 upvotes 5 months ago
      Lichen Planopilaris (LPP) is an autoimmune condition causing permanent hair loss and fibrosis, often misdiagnosed. Treatments include pioglitazone, topical corticosteroids, anti-inflammatory medication, and Jak inhibitors.
      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      in Research  830 upvotes 6 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community Testosterone and hair loss seeming irrelevance

      in Research/Science  79 upvotes 1 year ago
      The conversation is about the role of testosterone in hair loss and the effectiveness of different treatments. The conclusion is that DHT is the main culprit for hair loss, and finasteride has been proven to work long-term in maintaining and regrowing hair. Testosterone may have a minor effect, but it is not the primary cause of hair loss.

      community Joined the Dutasteride Master Race

      in Finasteride/Dutasteride  305 upvotes 1 day ago
      Dutasteride and finasteride are discussed for hair loss treatment, with users sharing experiences and debating their effectiveness and side effects. Celebrities are noted as common users, and there is debate over which treatment is superior.

      community A hill on which I will die: The DHT itch absolutely exists

      in Research/Science  211 upvotes 9 months ago
      The DHT itch is linked to hair loss and persists despite finasteride use; switching to dutasteride helped alleviate the itch and promoted regrowth. Some users suggest seborrheic dermatitis as a cause and recommend treatments like medicated shampoos, vitamin D, and minoxidil.

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