Reversible Hair Loss in Lichen Planopilaris: Regrowth With Low-Dose Naltrexone and Platelet-Rich Plasma

May 2022 in “ Journal of Drugs in Dermatology ”

Elizabeth G. Klein, Maria Karim, Randie H. Kim, Kristen Lo Sicco, Jerry Shapiro

lichen planopilaris low-dose naltrexone platelet-rich plasma intralesional corticosteroids topical clobetasol topical minoxidil finasteride doxycycline ketoconazole shampoo LPP LDN PRP clobetasol minoxidil Propecia Rogaine ketoconazole

TLDR Low-dose naltrexone and platelet-rich plasma can regrow hair in lichen planopilaris.

A 46-year-old woman with biopsy-confirmed lichen planopilaris (LPP) experienced significant hair regrowth in a previously scarred alopecic patch after treatment with low-dose naltrexone (LDN) and platelet-rich plasma (PRP). This occurred despite minimal response to prior therapies, including intralesional corticosteroids, topical clobetasol, topical minoxidil, finasteride, doxycycline, and ketoconazole shampoo. This case underscores the potential of LDN and PRP as effective treatments for LPP and highlights the need for more comprehensive research on treatment options and prognosis for LPP patients.

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community The Worst Hair Loss Condition You (MAY) have: LPP

in Research/Science 43 upvotes 1 year ago

Lichen Planopilaris (LPP) is an autoimmune condition causing permanent hair loss and fibrosis, often misdiagnosed. Treatments include pioglitazone, topical corticosteroids, anti-inflammatory medication, and Jak inhibitors.

community 8 years of hair loss, turning 30 next month

in Progress Pictures 151 upvotes 3 months ago

The user has been dealing with hair loss for 10 years, worsened by psoriasis, and uses minoxidil and finasteride. They seek advice on managing psoriasis and hair loss, with suggestions to see a dermatologist, try different shampoos, and be patient.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 1 year ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

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community Popular hair loss drug linked to higher suicide risk: compared to non-users, finasteride (Proscar/ Propecia) users have a markedly increased risk of depression, anxiety, and suicidal thoughts. Over 30 years of observation, 19,320 suicides were expected.

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Finasteride users may have an increased risk of depression, anxiety, and suicidal thoughts, though some attribute these issues to hair loss itself. The link between finasteride and mental health effects is debated, with varying user experiences.

community Joined the Dutasteride Master Race

in Finasteride/Dutasteride 582 upvotes 8 months ago

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