Graham-Little Piccardi Lassueur Syndrome and Review of the Literature
September 2021
in “
Clinical case reports
”
New to Tretinoin? There is a guide in the encyclopedia. Read the guide → Studysummary This case report documents the first known instance of Graham‐Little Piccardi Lassueur Syndrome in Saudi Arabia, observed in an adult dark-skinned male. Our plain-language summary of this paper — not a Tressless recommendation.
Graham‐Little Piccardi Lassueur Syndrome (GLPLS) is a rare variant of lichen planopilaris (LPP) characterized by a triad of patchy scarring alopecia of the scalp, non‐scarring alopecia of the axilla and groin, and numerous follicular keratotic papules over the body. This case report describes a 26-year-old dark-skinned Saudi male with GLPLS, marking the first reported case in Saudi Arabia. The patient exhibited severe pruritus, diffuse scarring alopecia of the scalp, and patchy alopecia in various body regions. Histopathological examination confirmed the diagnosis. Treatment aimed at halting disease progression and alleviating symptoms included hydroxychloroquine and topical tretinoin, which led to improvements in pruritus and follicular papules. The exact cause of GLPLS remains unknown, but it is likely an autoimmune condition. Early diagnosis and intervention are crucial for managing the disease.
