Graham-Little Piccardi Lassueur Syndrome and Review of the Literature

September 2021 in “ Clinical case reports ”

Fares A. Alkhayal, Fahad Alsudairy, Luluah Al Mubarak, Hind M. Almohanna

Graham‐Little Piccardi Lassueur Syndrome lichen planopilaris scarring alopecia non‐scarring alopecia follicular keratotic papules pruritus hydroxychloroquine tretinoin autoimmune condition GLPLS LPP itching Plaquenil Retin-A

TLDR GLPLS is a rare skin condition with specific hair loss and skin symptoms.

Graham‐Little Piccardi Lassueur Syndrome (GLPLS) is a rare variant of lichen planopilaris (LPP) characterized by a triad of patchy scarring alopecia of the scalp, non‐scarring alopecia of the axilla and groin, and numerous follicular keratotic papules over the body. This case report describes a 26-year-old dark-skinned Saudi male with GLPLS, marking the first reported case in Saudi Arabia. The patient exhibited severe pruritus, diffuse scarring alopecia of the scalp, and patchy alopecia in various body regions. Histopathological examination confirmed the diagnosis. Treatment aimed at halting disease progression and alleviating symptoms included hydroxychloroquine and topical tretinoin, which led to improvements in pruritus and follicular papules. The exact cause of GLPLS remains unknown, but it is likely an autoimmune condition. Early diagnosis and intervention are crucial for managing the disease.

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