Graham-Little Piccardi Lassueur Syndrome and Review of the Literature

September 2021 in “ Clinical case reports ”

Fares A. Alkhayal, Fahad Alsudairy, Luluah Al Mubarak, Hind M. Almohanna

Graham‐Little Piccardi Lassueur Syndrome lichen planopilaris scarring alopecia non‐scarring alopecia follicular keratotic papules pruritus hydroxychloroquine tretinoin autoimmune condition GLPLS LPP itching Plaquenil Retin-A

TLDR GLPLS is a rare skin condition with specific hair loss and skin symptoms.

Graham‐Little Piccardi Lassueur Syndrome (GLPLS) is a rare variant of lichen planopilaris (LPP) characterized by a triad of patchy scarring alopecia of the scalp, non‐scarring alopecia of the axilla and groin, and numerous follicular keratotic papules over the body. This case report describes a 26-year-old dark-skinned Saudi male with GLPLS, marking the first reported case in Saudi Arabia. The patient exhibited severe pruritus, diffuse scarring alopecia of the scalp, and patchy alopecia in various body regions. Histopathological examination confirmed the diagnosis. Treatment aimed at halting disease progression and alleviating symptoms included hydroxychloroquine and topical tretinoin, which led to improvements in pruritus and follicular papules. The exact cause of GLPLS remains unknown, but it is likely an autoimmune condition. Early diagnosis and intervention are crucial for managing the disease.

View this study on onlinelibrary.wiley.com →

Discuss this study in the Community →

Cited in this study

5 / 5 results

research Graham-Little Piccardi Lassueur Syndrome and Review of the Literature

5 citations , September 2021 in “Clinical case reports”

GLPLS is a rare skin condition with specific hair loss and skin symptoms.

research Tofacitinib for the Treatment of Lichen Planopilaris: A Case Series

79 citations , September 2018 in “Dermatologic therapy”

Oral tofacitinib can significantly improve recalcitrant lichen planopilaris.

research Lichen Planopilaris Epidemiology: A Retrospective Study of 80 Cases

37 citations , October 2015 in “Anais Brasileiros de Dermatologia”

Lichen planopilaris mostly affects women with fair skin and can look different on each person, needing early treatment to prevent hair loss.

research Treatment of Frontal Fibrosing Alopecia and Lichen Planopilaris: A Systematic Review

117 citations , March 2013 in “Journal of the European Academy of Dermatology and Venereology”

No effective treatment for frontal fibrosing alopecia was found, but oral 5-alpha-reductase inhibitors had the best response; for lichen planopilaris, topical corticosteroids were commonly used but had a high relapse rate.

research Lichen Planopilaris: Update on Diagnosis and Treatment

160 citations , March 2009 in “Seminars in Cutaneous Medicine and Surgery”

New insights show Lichen Planopilaris is a rare, scarring hair loss condition, hard to treat, mainly affecting middle-aged women, and significantly impacts mental health.

10 / 10 results

research 63-Year-Old Female with Diffuse Thinning of the Hair

January 2022 in “Clinical Cases in Dermatology”

Androgenetic alopecia, a common hair loss condition, can be treated with topical minoxidil, oral finasteride, or oral spironolactone, and new treatments like platelet-rich plasma, low-level laser therapy, and janus-kinase inhibitors are being explored.

research Acute Hair Loss Three Years After Bone Marrow Transplant

1 citations , January 2019 in “Skin appendage disorders”

A woman's sudden hair loss three years after a bone marrow transplant was a sign of chronic graft-versus-host disease but improved with treatment.

research Hair Disorders

August 2018 in “Oxford University Press eBooks”

The document's conclusion cannot be provided because the document cannot be parsed.

research Platelet-Rich Plasma: Alopecia Areata and Autoimmune Destruction of the Hair

May 2018 in “Journal of dermatology and dermatitis”

PRP is a promising treatment for autoimmune hair loss but its exact workings are not fully understood.

research Androgenetic Alopecia

January 2018

Androgenetic alopecia (AGA) is a common, hereditary hair loss condition that can be slowed but not permanently reversed with available therapies.

research Evaluation of Hair Loss

21 citations , May 1996 in “Current problems in dermatology”

Detailed patient history and physical exams are crucial for diagnosing hair loss.

research Androgenetic Alopecia, Trichotrophic Substances, and Histologic Studies of the Human Scalp

5 citations , October 1988 in “Clinics in Dermatology”

Minoxidil promotes hair growth but exact mechanism is unknown.