Novel Treatment Using Low-Dose Naltrexone for Lichen Planopilaris

    November 2017 in “ PubMed ”
    Lauren C. Strazzulla, Lorena Avila, Kristen Lo Sicco, Jerry Shapiro
    TLDR Low-dose naltrexone helps reduce symptoms and slow down lichen planopilaris without side effects.
    The document described a retrospective medical record review of four patients with lichen planopilaris (LPP) treated with low-dose naltrexone (3 mg/day). The treatment resulted in reduced symptoms of pruritus, clinical evidence of scalp inflammation, and disease progression. All patients tolerated the medication well without adverse effects. This case series was the first to demonstrate the beneficial effects of low-dose naltrexone for LPP, highlighting its potential as a well-tolerated and cost-effective treatment option.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 37 results

      community The Worst Hair Loss Condition You (MAY) have: LPP

      in Research/Science  43 upvotes 2 months ago
      Lichen Planopilaris (LPP) is an autoimmune condition causing permanent hair loss and fibrosis, often misdiagnosed. Treatments include pioglitazone, topical corticosteroids, anti-inflammatory medication, and Jak inhibitors.
      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 3 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community Testosterone and hair loss seeming irrelevance

      in Research/Science  81 upvotes 1 year ago
      The conversation is about the role of testosterone in hair loss and the effectiveness of different treatments. The conclusion is that DHT is the main culprit for hair loss, and finasteride has been proven to work long-term in maintaining and regrowing hair. Testosterone may have a minor effect, but it is not the primary cause of hair loss.

      community A hill on which I will die: The DHT itch absolutely exists

      in Research/Science  209 upvotes 6 months ago
      The DHT itch is linked to hair loss and persists despite finasteride use; switching to dutasteride helped alleviate the itch and promoted regrowth. Some users suggest seborrheic dermatitis as a cause and recommend treatments like medicated shampoos, vitamin D, and minoxidil.

      community C’est terrible - at my wits end

      in Female  443 upvotes 1 year ago
      A 29-year-old woman is experiencing gradual hair thinning since age 15, suspects Androgenic Alopecia, and has tried 5% minoxidil with little success. She has purchased various hair loss treatments including minoxidil, dutasteride, finasteride, and spironolactone, but is cautious about starting them due to potential interactions with her ADHD medication.

    Related Research

    6 / 6 results