Hair Growth Effects of Laminaria Japonica Extract and Growth Factor Mixture on a C57BL/6 Mouse Model

January 2016 in “ Biotechnology and Bioprocess Engineering ”

Bong Moo Lee, Sun-Hee Park, Yong Jig Lee, Eun Som Choi, Dae Hwan Park

Laminaria japonica extract IGF-1 VEGF hair re-growth follicle width follicle length IGF-1 gene expression TGF-ß gene expression hair follicle strengthening hair growth promotion alopecia L. japonica Insulin-like Growth Factor 1 Vascular Endothelial Growth Factor hair growth hair loss

Studysummary This animal study found that Laminaria japonica mixed with insulin-like growth factor-1 significantly promoted hair growth in mice, suggesting its potential use for treating alopecia pending further clinical trials. Our plain-language summary of this paper — not a Tressless recommendation.

In the 2016 study, researchers evaluated the hair growth effects of Laminaria japonica extract alone and in combination with growth factors IGF-1 and VEGF on a C57BL/6 mouse model. The study found that the group treated with L. japonica extract and IGF-1 had the most significant improvements in hair re-growth, follicle width, and length compared to control groups. Additionally, this combination led to increased IGF-1 gene expression and decreased TGF-ß gene expression, suggesting potential benefits for hair follicle strengthening and hair growth promotion. The study concluded that L. japonica extract mixed with IGF-1 could be a potential treatment for alopecia, but highlighted the necessity for clinical trials to confirm efficacy and assess side effects. The experiments involved groups of four to six mice each.

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