Radiofrequency Treatment Induces Fibroblast Growth Factor 2 Expression and Subsequently Promotes Neocollagenesis and Neoangiogenesis in the Skin Tissue

The study concluded that radiofrequency (RF) treatment effectively induced the expression of fibroblast growth factor 2 (FGF-2), promoting neocollagenesis and neoangiogenesis in skin tissue. RF treatment, with or without hydrolyzed collagen (HC), increased cellularity, intercellular substance accumulation, dermis thickness, microvessel density, and COX-2 levels in Wistar rats. The findings suggested that RF could be a beneficial non-invasive method for skin rejuvenation by enhancing the skin's structural and vascular components.