Radiofrequency Treatment Induces Fibroblast Growth Factor 2 Expression and Subsequently Promotes Neocollagenesis and Neoangiogenesis in the Skin Tissue

    May 2017 in “ Lasers in medical science ”
    Patrícia Fróes Meyer, Patrícia Oliveira, Flávia K B A Silva, Ana Clara Santos Costa, Caline R A Pereira, Sebastian Casenave, Rodrigo Marcel Valentim Silva, Luis Gonzaga Araújo-Neto, Sebastião David Santos-Filho, Eric Aizamaque, Hennes Gentil de Araújo, Mário Bernardo-Filho, Maria Goretti Freire de Carvalho, Ciro Dantas Soares
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    Studysummary This study found that radiofrequency treatment, with or without hydrolyzed collagen, increased dermis thickness, neocollagenesis, and FGF2 overexpression in rat skin tissue.
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    The study concluded that radiofrequency (RF) treatment effectively induced the expression of fibroblast growth factor 2 (FGF-2), promoting neocollagenesis and neoangiogenesis in skin tissue. RF treatment, with or without hydrolyzed collagen (HC), increased cellularity, intercellular substance accumulation, dermis thickness, microvessel density, and COX-2 levels in Wistar rats. The findings suggested that RF could be a beneficial non-invasive method for skin rejuvenation by enhancing the skin's structural and vascular components.
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