Microneedle Radiofrequency Induces Extracellular Matrix Remodeling Through Fibroblast Activation: A Histological Study in a Porcine Model
May 2025
in “
Lasers in Surgery and Medicine
”
TLDR Microneedle radiofrequency helps skin repair and rejuvenate by activating fibroblasts and remodeling the skin's structure.
Microneedle radiofrequency (MRF) enhances skin regeneration and rejuvenation by promoting the synthesis of Collagen I and III, increasing the Collagen I/III ratio, and regulating the expression of MMP-1, MMP-3, MMP-9, TGF-β, and EGF. These factors collectively activate fibroblasts, leading to extracellular matrix (ECM) remodeling. Additionally, preliminary findings indicate that adipose-derived stem cells (ADSCs) may play a role in these regenerative processes.
