Synergistic Effect of Microneedle-Delivered Extracellular Matrix Compound and Radiofrequency on Rejuvenation of Periorbital Wrinkles
July 2022
in “
Frontiers in Medicine
”
TLDR Combining microneedle-delivered ECM and radiofrequency improves skin elasticity and thickness more than ECM alone.
The study investigated the synergistic effects of extracellular matrix compound (ECM-C) delivered via microneedles (MN) combined with radiofrequency (RF) on periorbital wrinkles in 25 participants. Results showed that both treatments reduced wrinkles and increased skin hydration, but the combination of ECM-C via MN and RF led to greater improvements in skin elasticity and thickness compared to ECM-C via MN alone. However, subjective assessments using the Crow's Feet Grading Scale (CFGS) and Global Aesthetic International Scale (GAIS) did not show significant differences between the two treatment methods.
