4 citations
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November 2023 in “Journal of Cosmetic Dermatology” In this study, researchers found that negative pressure fractional microneedle radiofrequency significantly improved periorbital wrinkles, hydration, and dermal thickness in patients with periorbital aging, while also increasing orderly collagen and elastic fibers, with minimal adverse effects reported.
3 citations
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May 2025 in “Lasers in Surgery and Medicine” This study suggested that MRF may support skin regeneration and rejuvenation by promoting collagen synthesis and regulating factors involved in fibroblast activation and ECM remodeling, with preliminary findings indicating ADSCs might aid these processes.
December 2022 in “Физиотерапия, бальнеология и реабилитация” This integrative literature analysis found that radiofrequency is widely used in dermatocosmetology for facial skin rejuvenation due to its high efficiency and safety, but noted a lack of comprehensive studies on radiofrequency microneedling, which may enhance safety and efficacy over traditional methods.
January 2019 in “Archives of dermatology and skin care” This study found that combining microneedling with oral collagen supplementation may improve wrinkles and texture better than microneedling alone for skin rejuvenation.
4 citations
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October 2024 in “Aesthetic Plastic Surgery” In this study, combining microneedle and sublative fractional radiofrequency treatments significantly improved skin tightening, texture, collagen organization, and satisfaction in individuals with moderate photoaging, while reducing abnormal elastin after three months.