TLDR Combining microneedle-delivered ECM and radiofrequency improves skin elasticity and thickness more than ECM alone.
The study examined the effects of combining microneedle-delivered extracellular matrix compound (ECM-C) with radiofrequency (RF) on periorbital wrinkles in 25 Asian women aged 35-65. Both treatments improved skin hydration, elasticity, and thickness, with the RF combination showing greater improvements. Periocular wrinkle scores decreased more significantly with the combined treatment, and participants reported high satisfaction. The study concluded that the combination of ECM-C and RF enhanced rejuvenation effects on periorbital wrinkles, proving to be safe, effective, and well-tolerated.
15 citations
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March 2020 in “Journal of cosmetic dermatology” PRP is effective for improving the appearance around the eyes.
18 citations
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August 2018 in “Facial Plastic Surgery Clinics of North America” Lasers, microneedling, and PRP improve skin rejuvenation and repair, with PRP enhancing the effects when combined with other treatments.
92 citations
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June 2017 in “Journal of Plastic Reconstructive and Aesthetic Surgery” Microneedling is a safe and effective treatment for various skin conditions, often preferred for its fewer side effects and shorter recovery time.
25 citations
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June 2015 in “Clinical, Cosmetic and Investigational Dermatology” Microneedling helps increase the absorption of a melanin product into hair follicles, which may improve laser hair removal effectiveness.
68 citations
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May 2015 in “Indian Journal of Dermatology” Microneedling can effectively promote new hair growth in men with hair loss who didn't improve with traditional treatments.
136 citations
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January 2013 in “International Journal of Trichology”
Microneedle technology is effective for skin rejuvenation and enhancing cosmeceutical delivery, with ongoing innovation and increasing commercialization.
2 citations
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August 2025 in “Pharmaceutics” PN hydrates skin; PDRN heals and regenerates skin and hair.
July 2024 in “Periodontology 2000” Autologous platelet concentrates show promise in esthetic treatments but need more standardized research.
February 2009 in “Journal of the American Academy of Dermatology” 3 citations
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October 2024 in “International Journal of Molecular Sciences” CRET therapy affects inflammation in skin cells by changing cytokine levels and activating certain proteins.
