TLDR Combining microneedle-delivered ECM and radiofrequency improves skin elasticity and thickness more than ECM alone.
The study investigated the synergistic effects of extracellular matrix compound (ECM-C) delivered via microneedles (MN) combined with radiofrequency (RF) on periorbital wrinkles in 25 participants. Results showed that both treatments reduced wrinkles and increased skin hydration, but the combination of ECM-C via MN and RF led to greater improvements in skin elasticity and thickness compared to ECM-C via MN alone. However, subjective assessments using the Crow's Feet Grading Scale (CFGS) and Global Aesthetic International Scale (GAIS) did not show significant differences between the two treatment methods.
15 citations
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March 2020 in “Journal of cosmetic dermatology” PRP is effective for improving the appearance around the eyes.
18 citations
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August 2018 in “Facial Plastic Surgery Clinics of North America” Lasers, microneedling, and PRP improve skin rejuvenation and repair, with PRP enhancing the effects when combined with other treatments.
92 citations
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June 2017 in “Journal of Plastic Reconstructive and Aesthetic Surgery” Microneedling is a safe and effective treatment for various skin conditions, often preferred for its fewer side effects and shorter recovery time.
25 citations
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June 2015 in “Clinical, Cosmetic and Investigational Dermatology” Microneedling helps increase the absorption of a melanin product into hair follicles, which may improve laser hair removal effectiveness.
68 citations
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May 2015 in “Indian Journal of Dermatology” Microneedling can effectively promote new hair growth in men with hair loss who didn't improve with traditional treatments.
136 citations
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January 2013 in “International Journal of Trichology”
July 2024 in “Periodontology 2000” Autologous platelet concentrates show promise in esthetic treatments but need more standardized research.
Microneedle technology is effective for skin rejuvenation and enhancing cosmeceutical delivery, with ongoing innovation and increasing commercialization.
February 2009 in “Journal of the American Academy of Dermatology” 
19 citations
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September 2015 in “Therapeutic Delivery” Active transdermal technologies in cosmetics help deliver skin treatments effectively, but their safety and effectiveness depend on skin type and treatment choice.
4 citations
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January 2022 in “Yonsei Medical Journal” Microneedles are a promising method for drug delivery, offering efficient and convenient alternatives with fewer side effects.
