Radiofrequency Currents Modulate Inflammatory Processes in Keratinocytes

The study examines the effects of Capacitive Resistive Electric Transfer (CRET) therapy using radiofrequency currents on human keratinocytes, focusing on inflammatory processes and cell proliferation. CRET therapy was found to modulate cytokine production, increasing MCP-1, TNF-α, and IL-6 while decreasing IL-8, and enhance keratinocyte proliferation. It also influenced the expression of matrix metalloproteinases and activated proteins such as EGFR, NF-κB, and ERK1/2. These findings suggest that CRET therapy can effectively alter cytokine production and modulate inflammatory responses via the EGF receptor and the ERK1/2/NF-κB pathway, indicating its potential as a therapeutic strategy for managing inflammatory skin conditions.