Effects of RF Electric Currents on Hair Follicle Growth and Differentiation: A Possible Treatment for Alopecia

    Miryam Martínez-Pascual, Silvia Sacristán, Elena Toledano‐Macías, Pablo Naranjo, María Luisa Hernández‐Bule
    TLDR RF-based therapies might help treat hair loss.
    The study investigates the effects of Capacitive Resistive Electric Transfer (CRET) therapy using radiofrequency (RF) currents on hair follicles from patients with androgenic alopecia (AGA). CRET increased cell proliferation and decreased cell death in hair follicles, particularly with the standard 448 kHz sinusoidal signal. This treatment also led to an increase in melanoblasts and thickened the epidermis surrounding the hair follicle. A parallel clinical trial with 20 female patients showed a 10-15% increase in hair density. These findings suggest that CRET therapy could be a promising non-invasive treatment for alopecia, though further clinical trials are needed to confirm its effectiveness.
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