Electric Stimulation at 448 kHz Modulates Proliferation and Differentiation of Follicle Dermal Papilla Cells

The study investigates the effects of 448 kHz capacitive resistive electrical transfer (CRET) on dermal papilla cells (DPCs), which are crucial for hair growth and regeneration. The research found that CRET, using both standard and modulated signals, enhances DPC proliferation and survival by increasing p-MAPK-ERK1/2 and cyclin D1 expression while reducing p53 and caspase 3 expression. Additionally, CRET transiently boosts β-catenin and anagen phase markers like versican and PPARγ, which are associated with hair growth and follicle maintenance. These findings suggest that CRET therapy can induce molecular changes in DPCs that promote hair regeneration, offering a potential alternative to pharmacological treatments for alopecia.