Ent-Kaurane-Type Diterpenoids from Isodonis Herba Activate Human Hair Follicle Dermal Papilla Cells Proliferation via the Akt/GSK-3β/β-Catenin Transduction Pathway

January 2021 in “ Journal of Natural Medicines ”

Yoshiaki Manse, Fenglin Luo, Kazuhiro Kato, Akane Okazaki, Eriko Okada-Nishida, Mitsuhiro Yanagida, Sho Nakamura, Toshio Morikawa

ent-kaurane-type diterpenoids Isodonis Herba hair follicle dermal papilla cells Akt/GSK-3β/β-catenin transduction pathway cell proliferation hair growth

TLDR Ent-kaurane-type diterpenoids from Isodonis Herba may promote hair growth by boosting cell proliferation.

The study investigated the effects of ent-kaurane-type diterpenoids from Isodonis Herba on human hair follicle dermal papilla cells and found that these compounds activated cell proliferation via the Akt/GSK-3β/β-catenin transduction pathway. This pathway played a significant role in regulating hair growth, suggesting that ent-kaurane-type diterpenoids could potentially be used to promote hair growth by enhancing the proliferation of dermal papilla cells. The study provided insights into the molecular mechanisms underlying hair follicle cell proliferation, which could inform future treatments for hair loss.

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