Nucleic Acid-Induced Chemokine Expression in Keratinocytes: Implications for Skin Inflammation

    November 2025 in “ PLoS ONE ”
    Judit Danis, E. Kelemen, Fanni Balogh … Márta Széll
    Studysummary This study found that synthetic RNA and DNA trigger significant increases in certain chemokines in human keratinocytes, predominantly via NF-κB activation, without evidence of alternative splicing, suggesting other regulatory pathways may be involved.
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    Research cited in this study 2

    1. Double-Stranded RNA Induces Inflammation via the NF-κB Pathway and Inflammasome Activation in the Outer Root Sheath Cells of Hair Follicles Scientific reports · 2017
    2. Transcriptional Profiling in Alopecia Areata Defines Immune and Cell Cycle Control Related Genes Within Disease-Specific Signatures Genomics · 2010