TLDR Nucleic acids trigger chemokine production in skin cells, affecting skin inflammation.
This study investigates the role of nucleic acids in inducing chemokine expression in human keratinocytes, which is relevant to skin diseases like psoriasis, atopic dermatitis, vitiligo, and alopecia areata. The researchers found that cytoplasmic nucleic acids significantly induce the expression of chemokines such as CCL2, CXCL10, and CX3CL1 through NF-κB activation. However, the specific pattern recognition receptors involved remain unidentified. Additionally, no alternative splicing of these chemokines was observed, indicating that other regulatory mechanisms might be at play in chemokine activity.
22 citations
,
March 2017 in “Scientific reports” Double-stranded RNA causes inflammation in hair follicle cells, which may help understand and treat alopecia areata.
61 citations
,
September 2010 in “Genomics” The study found that immune responses disrupt hair growth cycles, causing hair loss in alopecia areata.
January 2025 in “Repository of the Academy's Library (Library of the Hungarian Academy of Sciences)” Nucleic acids trigger chemokine production in skin cells, affecting skin inflammation.
7 citations
,
January 2020 in “The journal of investigative dermatology/Journal of investigative dermatology” NIPP1 is important for healthy skin and could help treat skin inflammation.
60 citations
,
November 2023 in “Biology” Aging skin causes inflammation that affects the whole body.
610 citations
,
April 2014 in “Nature Reviews Immunology” The document concludes that understanding how the skin's immune system and inflammation work is complex and requires more research to improve treatments for skin diseases.
9 citations
,
August 2021 in “International journal of molecular sciences” PPARγ is essential for maintaining healthy skin, controlling inflammation, and ensuring proper skin barrier function.
