Comparison of Polynucleotide and Polydeoxyribonucleotide in Dermatology: Molecular Mechanisms and Clinical Perspectives

Polynucleotide (PN) and polydeoxyribonucleotide (PDRN) are DNA-derived biopolymers with distinct roles in dermatology due to differences in polymer length and molecular weight. PN, with longer DNA fragments, is crucial for extracellular matrix remodeling, while PDRN, with shorter sequences, improves skin condition through adenosine receptor activation and supports nucleotide synthesis. This review compares their molecular characteristics and functions, emphasizing their applications in esthetic and regenerative medicine, and highlights recent advances that could inform optimized treatment strategies and evidence-based clinical practice.