Expert Perspectives: Evidence-Based Applications of Polynucleotides in Aesthetic Medicine and Dermatology
January 2026
in “
Clinical Cosmetic and Investigational Dermatology
”
Studysummary This expert opinion article presents insights from dermatologists and aesthetic physicians on using polynucleotides (Rejuran®) for skin hydration, rejuvenation, structural support, barrier repair, and scar remodeling, noting their favorable safety profile but highlighting the need for more robust evidence and research. Our plain-language summary of this paper — not a Tressless recommendation.
Polynucleotides (PNs) are gaining traction in aesthetic dermatology for their potential in improving skin conditions through mechanisms like tissue remodeling and hydration. This article compiles expert opinions on using PNs (Rejuran ®) for skin hydration, structural support, barrier repair in conditions like rosacea and eczema, and scar remodeling. PNs are noted for their safety, with no reported granuloma or vascular occlusion cases, making them suitable for sensitive skin. Despite promising applications, the evidence is limited, necessitating further research, including randomized trials, to validate their efficacy and standardize treatment protocols.
