May 2025 in “International Society of Hair Restoration Surgery” This study suggests that exosomes derived from mesenchymal stem cells may promote hair growth and improve skin health by enhancing dermal papilla cell proliferation and modulating inflammation and oxidative stress.
May 2025 in “Journal of International Medical Research” In this study, micrografting technology was found to potentially shorten healing time compared to other grafting techniques, especially in treating burns, though results showed high heterogeneity and a risk of bias.
This study found that an exosome formulation with plant extracts significantly increased hair regrowth in men with male pattern alopecia compared to a placebo, without notable adverse effects.
16 citations
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March 2025 in “International Journal of Molecular Sciences” This review analyzed 12 clinical studies on extracellular vesicle therapies, finding potential benefits for skin aging, acne scars, alopecia, and wound healing, but highlighted significant challenges like production standardization and lack of large-scale studies.
December 2024 in “Journal of Cosmetic Dermatology” This study found that exosomes derived from platelet-rich plasma show preclinical promise for wound healing but lack sufficient data for other dermatological uses like hair growth and skin rejuvenation.
October 2024 in “Aesthetic Plastic Surgery” In this multicenter observational study, researchers found that using micrografts with human follicle mesenchymal stem cells increased hair density significantly in both male and female patients with mild to moderate androgenic alopecia after 12 months, suggesting a viable alternative for hair regrowth.
October 2024 in “Skin Appendage Disorders” This study evaluated the effects of autologous micrografts for androgenetic alopecia, reporting moderate improvements in hair loss reduction and hair density among most patients after treatment, with satisfactory results noted in patient satisfaction and treatment tolerability.
August 2024 in “Aesthetic Plastic Surgery” In this study, injecting foreskin-derived mesenchymal stromal cell exosomes into the scalps of men with androgenetic alopecia significantly increased hair density and patient satisfaction without side effects over a 12-week period.
9 citations
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July 2024 in “JAAD reviews.” This review discusses the role of extracellular vesicles in dermatology for therapeutic, diagnostic, and prognostic purposes, highlighting the lack of validated findings and the necessity for more rigorous clinical trials.
July 2024 in “Clinical Cosmetic and Investigational Dermatology” This review summarizes recent advancements in using exosomes for promoting hair growth, finding that exosomes from various cells, like dermal papilla and mesenchymal stem cells, show promise as a potential new treatment route for alopecia.
4 citations
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February 2024 in “Dermatology and Therapy” The study found that a single autologous micrografting treatment using Rigenera® technology significantly improved the appearance of stretch marks in healthy women after three months, showing greater enhancements in skin properties compared to microneedling alone.
January 2024 in “Biomedicines” This study found that a single injection of autologous cell micrografts significantly improved hair condition in women with androgenetic alopecia six months post-treatment.
8 citations
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June 2023 in “Journal of clinical medicine” This study reviews the use of nanofat in facial rejuvenation and cosmetic surgery, highlighting its potential for improving skin appearance and treating conditions like wrinkles and acne scars, yet emphasizes the need for further research into its long-term efficacy and safety.
1 citations
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June 2023 in “Journal of Cosmetic Dermatology” This study found that while clinical evidence is limited, early preclinical results suggest exosome treatment may enhance hair growth and warrant further research for therapeutic use in alopecia.
This study reports that mesenchymal stromal cell-derived extracellular vesicle injections led to complete hair regrowth in a patient with persistent chemotherapy-induced alopecia.
10 citations
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February 2022 in “Journal of cosmetic dermatology” This abstract provides information about data availability and author affiliations but does not contain results or conclusions from the study itself.
January 2022 in “Aesthetic surgery journal” In this study, intradermal injections of extracellular vesicles over six months were reported to be safe and effective in improving hair growth among patients with pattern hair loss, with favorable response linked to specific patient factors and treatment volumes.
3 citations
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November 2021 in “Clinical, Cosmetic and Investigational Dermatology” In this study, a single application of autologous cellular micrografts showed short-term favorable responses in up to two-thirds of patients with androgenetic alopecia.
11 citations
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August 2021 in “Stem Cell Research & Therapy” This study reports that a single transplantation of autologous stromal vascular fraction significantly increased hair density and keratin score in androgenic alopecia patients within six months.
3 citations
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December 2020 in “Journal of Cosmetic Dermatology” This study reported that autologous whole fat injection in the scalp considerably increased hair growth in patients with androgenetic alopecia.
3 citations
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December 2020 in “Journal of the turkish academy of dermatology” This study concluded that stromal vascular fraction treatment was effective in increasing hair density and thickness in patients with androgenetic alopecia over a three-month period.
65 citations
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July 2020 in “Science Advances” Dermal exosomes with miR-218-5p boost hair growth by controlling β-catenin signaling.
8 citations
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February 2020 in “Aesthetic Surgery Journal” This study found that early male hair loss treatment with Puregraft fat and low-dose adipose-derived regenerative cells increased terminal hair counts at 24 weeks compared to a saline control, indicating promise for androgenetic alopecia treatment.
46 citations
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January 2020 in “Theranostics” This study demonstrated that OSA hydrogels enhanced the stability and retention of dermal papilla-derived extracellular vesicles, which significantly improved hair regeneration in both cultured human hair and a mouse depilation model.
14 citations
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October 2019 in “Journal of Cellular Physiology” This study found that dermis micrografting improved hair growth and density in patients with androgenetic alopecia over 4, 6, and 12 months, suggesting it could be a novel treatment option.
20 citations
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September 2019 in “Journal of Cosmetic Dermatology” This study found that combining stromal vascular fraction with PRP injections significantly improved hair density and reduced hair loss more effectively than PRP alone in patients with androgenetic alopecia.
33 citations
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September 2019 in “Dermatologic Surgery” This study found that intradermal administration of adipose-derived stem cell–conditioned medium significantly increased hair density and dermal thickness, suggesting potential regenerative effects on both hair follicles and the interfollicular scalp in patients with alopecia.
88 citations
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July 2019 in “International Journal of Molecular Sciences” In this study of patients with Androgenic Alopecia, micro-grafts containing HD-AFSCs resulted in significantly improved hair density and follicle count over 11 months compared to a saline solution, suggesting a potential alternative therapy for hair regrowth.
40 citations
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March 2018 in “Aesthetic Surgery Journal” This study found that a single injection of platelet-rich stroma significantly increased hair density in men with androgenetic alopecia within 6 to 12 weeks, with no reported side effects.
2 citations
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September 2017 in “Plastic and reconstructive surgery. Global open” This pilot study found that a single session of nanofat treatment may increase hair thickness and density in male patients with androgenic alopecia, with effects lasting up to 12 months in some cases, though results varied.
30 citations
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July 2017 in “Stem cells and cloning” This study found that scalp injection of fat enriched with stem cells may offer a promising alternative for treating early genetic alopecia in both men and women.
3 citations
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June 2017 in “Medical lasers” In this case report, hair graying improved in a patient with male pattern hair loss after combined treatment with thulium laser energy and polydeoxyribonucleotide injections, suggesting potential therapeutic benefits.
86 citations
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June 2017 in “Stem cell investigation” This study reported that using human follicle stem cells isolated from hair bulge areas increased hair density by about 29% over baseline in patients with androgenetic alopecia, with significant improvements observed 23 weeks after the last treatment.
18 citations
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September 2016 in “International Journal of Molecular Sciences” This study reports that PDRN, commonly used for wound healing, may also have anti-melanogenesis and potential skin whitening effects in both experimental models and clinical settings.
20 citations
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January 2014 in “Journal of Cosmetics, Dermatological Sciences and Applications” This study suggests that applying a suspension of adipose-derived cells during hair transplantation may enhance wound healing and promote continued hair growth shortly after the procedure.
235 citations
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January 2011 in “Journal of Clinical Investigation” This study found that androgenetic alopecia may involve a defect in the conversion of hair follicle stem cells to progenitor cells, as demonstrated by a reduced presence of progenitor cells in bald scalp samples.
344 citations
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June 2006 in “American Journal Of Pathology” Human hair follicles can provide stem cells for regenerative medicine.
90 citations
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August 2004 in “Physiological Genomics” This study found that coculturing human hair follicle keratinocyte stem cells with dermal papilla cells increased expression of the hair-specific keratin 6hf gene, which requires β-catenin/lef-1 signaling for hair differentiation.
277 citations
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June 2003 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings” This article reviews the role of epithelial-mesenchymal interactions in hair follicle morphogenesis and the hair cycle, suggesting potential paths for developing treatments for hair growth disorders but providing no new clinical findings.