Effectiveness of Extracellular Vesicle Application in Skin Aging Treatment and Regeneration: Do We Have Enough Evidence from Clinical Trials?

    March 2025 in “ International Journal of Molecular Sciences ”
    Anna Domaszewska-Szostek, Marta Krzyżanowska, Agnieszka Polak, Monika Puzianowska‐Kuźnicka
    Studysummary This review analyzed 12 clinical studies on extracellular vesicle therapies, finding potential benefits for skin aging, acne scars, alopecia, and wound healing, but highlighted significant challenges like production standardization and lack of large-scale studies.
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    Research cited in this study 12

    1. Effectiveness of Exosome Treatment in Androgenetic Alopecia: Outcomes of a Prospective Study Aesthetic Plastic Surgery · 2024
    2. The Roles of Exosomes in Regulating Hair Follicle Growth Clinical Cosmetic and Investigational Dermatology · 2024
    3. Hydrogel-Mediated Extracellular Vesicles for Enhanced Wound Healing: The Latest Progress and Their Prospects for 3D Bioprinting Journal of nanobiotechnology · 2024
    4. Exosomal MicroRNA-Based Therapies for Skin Diseases Regenerative therapy · 2023
    5. Environmental Air Pollutants Affecting Skin Functions With Systemic Implications International Journal of Molecular Sciences · 2023
    6. Stem Cell-Derived Exosomes: Emerging Therapeutic Opportunities for Wound Healing Stem cell research & therapy · 2023
    7. Therapeutic Values of Exosomes in Cosmetics, Skin Care, Tissue Regeneration, and Dermatological Diseases Cosmetics · 2023
    8. Mesenchymal Stem Cell-Derived Extracellular Vesicles for Therapeutic Use and in Bioengineering Applications Cells · 2022
    9. Human Adipose-Derived Mesenchymal Stem Cells-Derived Exosomes Encapsulated in Pluronic F127 Hydrogel Promote Wound Healing and Regeneration Stem Cell Research & Therapy · 2022
    10. Exploring the Potential of Mesenchymal Stem Cell-Derived Exosomes for the Treatment of Alopecia Regenerative Engineering and Translational Medicine · 2021
    11. Neuroimmunology of Stress: Skin Takes Center Stage Journal of Investigative Dermatology · 2006
    12. Neuroimmunoendocrine Circuitry of the Brain-Skin Connection Trends in Immunology · 2005