Environmental Air Pollutants Affecting Skin Functions With Systemic Implications

The review highlights the detrimental effects of environmental air pollutants, such as particulate matter and ozone, on skin health and their systemic implications. These pollutants compromise skin integrity by inducing oxidative stress and inflammation, exacerbating conditions like acne, alopecia, and dermatitis. The aryl hydrocarbon receptor (AhR) is central to these processes, mediating both harmful and protective responses. Air pollution also reduces vitamin D synthesis by blocking UVB rays, contributing to skin disorders and cancers. Preventive strategies include anti-pollution skincare and targeting the AhR/Nrf2 pathway, with potential treatments like tapinarof showing promise in clinical trials. Addressing air pollution is crucial to mitigate its harmful effects on skin and overall health.