Efficacy and Safety of Autologous Cell-Based Therapies for Atrophic Acne Scar Treatment: An Updated Systematic Review and Meta-Analysis with In-Depth Methodological and Clinical Insights

    March 2026 in “ Frontiers in Cell and Developmental Biology ”
    Shuang Zhang, Yanxia Ren, Xudong Hong … Xudong Zhang
    Studysummary This meta-analysis found that autologous cell-based therapies, especially stromal vascular fraction, significantly improved atrophic acne scars over control treatments, enhancing both clinical and patient-reported outcomes.
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    Research cited in this study 8

    1. Treatment of Acne Scar Contraction Using Autologous Cultured Epithelial Sheet Transplantation: A Report of Four Cases Cureus · 2025
    2. Autologous Platelet Concentrates in Aesthetic Medicine Periodontology 2000 · 2024
    3. Regenerative Medicine in the Treatment of Specific Dermatologic Disorders: A Systematic Review of Randomized Controlled Clinical Trials Stem cell research & therapy · 2024
    4. The Efficacy and Safety of Autologous Epidermal Cell Suspensions for Re-Epithelialization of Skin Lesions: A Systematic Review and Meta-Analysis of Randomized Trials Skin Research and Technology · 2024
    5. Nanofat in Plastic Reconstructive, Regenerative, and Aesthetic Surgery: A Review of Advancements in Face-Focused Applications Journal of clinical medicine · 2023
    6. No Evidence for Follicular Keratinocyte Hyperproliferation in Acne Lesions Compared to Autologous Healthy Hair Follicles Experimental Dermatology · 2018
    7. Hidradenitis Suppurativa and Wound Management ˜The œinternational journal of lower extremity wounds/International journal of lower extremity wounds · 2015
    8. Systematic Review of the Use of Platelet-Rich Plasma in Aesthetic Dermatology Journal of Cosmetic Dermatology · 2015