The Investigation of the Efficacy and Safety of Stromal Vascular Fraction in the Treatment of Nanofat-Treated Acne Scar: A Randomized Blinded Controlled Clinical Trial

July 2022 in “ Stem Cell Research & Therapy ”

Elham Behrangi, Sepideh Moradi, Mohammadreza Ghassemi, Azadeh Goodarzi, Amirreza Hanifnia, Sona Zare, Maryam Nouri, Abbas Dehghani, Azadeh Seifadini, Mohammad Ali Nilforoushzadeh, Masoumeh Roohaninasab

stromal vascular fraction nanofat acne scars collagen dermal thickness

Studysummary This study concluded that using adipose tissue-derived stromal vascular fraction significantly improved acne scars by increasing collagen content and skin thickness compared to nanofat alone. Our plain-language summary of this paper — not a Tressless recommendation.

This study investigated the efficacy and safety of stromal vascular fraction (SVF) in treating nanofat-treated acne scars in a randomized, single-blinded clinical trial with 7 patients. The trial compared nanofat alone versus nanofat combined with SVF on different sides of the face. The combination treatment led to improvements in scar size, dermal thickness, and acne scar grade, with higher satisfaction levels among physicians and patients. However, by the third month, no significant differences were observed between the injected and control sides in sonographic variables. The study concluded that SVF could enhance the therapeutic effects of nanofat in acne scar treatment, but the small sample size limited the strength of the findings, and further research with a larger sample size was recommended.

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