The Therapeutic, Diagnostic, And Prognostic Values Of Extracellular Vesicles (Exosomes) In Dermatology: A Systematic Review

July 2024 in “ JAAD reviews. ”

Taissa Novis, Adriano Henrique Gomes Menezes, Luan Cavalcante Vilaça Lima, Jan Lötvall, Israel Júnior Borges do Nascimento, Christina Maeda Takiya

extracellular vesicles exosomes dermatology therapeutic efficacy cosmeceuticals

TLDR Extracellular vesicles show potential in dermatology, but more research is needed for validation.

This systematic review evaluates the potential of extracellular vesicles (EVs), particularly exosomes, in dermatology, analyzing 52 studies with data from 3,066 patients. EVs show promise for therapeutic, diagnostic, and prognostic applications in conditions like alopecia, atopic dermatitis, and skin aging. For instance, ASC-exosomes improved hair density and thickness, and XoFlo treatment showed positive hair growth results. However, the evidence is limited by methodological inconsistencies and small sample sizes, with no EV-based therapeutics approved in dermatology. Further robust clinical trials are needed to confirm efficacy, support regulatory approval, and explore cosmeceutical uses.

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