Exosomes in Dermatology: A Comprehensive Review of Current Applications, Clinical Evidence, and Future Directions

    June 2025 in “ International Journal of Dermatology ”
    William J. Nahm, Christos Nikas, Mohamad Goldust, Nadine C. Horneck, Juan Antonio Cervantes, Joshua Burshtein, Maria M. Tsoukas
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    TLDR Exosomes could transform skin treatments but face technical and regulatory hurdles.
    Exosomes are emerging as significant agents in dermatology, with applications in skin aging, scarring, hair restoration, and melasma, as well as potential treatments for inflammatory conditions like atopic dermatitis. They also hold promise as biomarkers for disorders such as psoriasis, vitiligo, and melanoma. Despite their potential, challenges such as standardizing isolation protocols, optimizing delivery systems, and establishing regulatory frameworks need to be addressed. Future directions include engineered exosomes with better targeting, plant-derived formulations, and combination therapies. While exosome-based therapies could revolutionize dermatological treatments, their widespread clinical adoption depends on overcoming these technical and regulatory challenges.
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