Exosomes in Dermatology: A Comprehensive Review of Current Applications, Clinical Evidence, and Future Directions

    June 2025 in “ International Journal of Dermatology ”
    William J. Nahm, Christos Nikas, Mohamad Goldust … Maria M. Tsoukas
    Studysummary This review highlights that exosomes are showing promise as therapeutic, prognostic, and diagnostic agents in dermatology, with clinical studies suggesting efficacy for skin aging, scarring, hair restoration, and inflammatory conditions, though challenges in standardization and regulation remain.
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    Research cited in this study 14

    1. Effectiveness of Exosome Treatment in Androgenetic Alopecia: Outcomes of a Prospective Study Aesthetic Plastic Surgery · 2024
    2. The Efficacy of Adipose Stem Cell-Derived Exosomes in Hair Regeneration Based on a Preclinical and Clinical Study International Journal of Dermatology · 2024
    3. The Emerging Role of Exosomes in the Treatment of Hair Loss International Journal of Dermatology · 2024
    4. Rose Stem Cell-Derived Exosomes for Hair Regeneration Enhancement via Noninvasive Electroporation in Androgenetic Alopecia Journal of Cosmetic Dermatology · 2024
    5. The Roles of Exosomes in Regulating Hair Follicle Growth Clinical Cosmetic and Investigational Dermatology · 2024
    6. Present and Future Use of Exosomes in Dermatology Indian Journal of Dermatology/Indian journal of dermatology · 2024
    7. Hair Repigmentation of Poliosis Circumscripta in Androgenetic Alopecia Patient Treated With Exosomes and Fractional Picosecond Laser Journal of Cosmetic Dermatology · 2024
    8. A Comprehensive Review of the Medical and Cosmetic Applications of Exosomes in Dermatology Journal of Cosmetic Dermatology · 2024
    9. Exosomes for Hair Growth and Regeneration Journal of Bioscience and Bioengineering · 2023
    10. Exosomes: A Promising Strategy for Repair, Regeneration and Treatment of Skin Disorders Cells · 2023
    11. Treatment of Persistent Chemotherapy-Induced Hair Loss (Alopecia) With Human Mesenchymal Stromal Cells Exosome Enriched Extracellular Vesicles: A Case Report Heliyon · 2023
    12. Effects of Exosomes from Adipose-Derived Stem Cells on Hair Loss: A Retrospective Analysis of 39 Patients Journal of cosmetic dermatology · 2022
    13. Biomaterials Functionalized with MSC Secreted Extracellular Vesicles and Soluble Factors for Tissue Regeneration Advanced functional materials · 2020
    14. Exosome for Hair Regeneration: From Bench to Bedside Journal of the American Academy of Dermatology · 2019