Treatment Strategies for Cutaneous and Oral Mucosal Side Effects of Oncological Treatment in Breast Cancer: A Comprehensive Review

August 2025 in “ Biomedicines ”

Sanja Brnić, Bruno Špiljak, Lucija Zanze, Ema Barac, Robert Likić, Liborija Lugović‐Mihić

cutaneous adverse events oral mucosal adverse events chemotherapy targeted therapy hormonal therapy radiotherapy immunotherapy nanoparticle-based delivery systems

Studysummary This review highlights the significant impact of cutaneous and oral mucosal adverse events on patients undergoing breast cancer treatment, emphasizing the need for early detection and comprehensive management to maintain treatment adherence and enhance patient care.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

This comprehensive review addresses the cutaneous and oral mucosal side effects of breast cancer treatments, emphasizing the importance of early detection, accurate classification, and multidisciplinary management to mitigate these effects. Common side effects include alopecia, mucositis, and hand-foot syndrome, which can significantly impact patients' quality of life and treatment adherence. The review highlights emerging strategies such as nanoparticle-based delivery systems and personalized interventions to reduce toxicity without compromising efficacy. It also underscores the need for patient education and supportive care to enhance the therapeutic experience and adherence in breast cancer patients. Various management strategies, including the use of topical and systemic treatments, are discussed to address skin and nail toxicities, photosensitivity, and other dermatologic adverse events. The integration of precision oncology and genomic profiling has advanced breast cancer treatment but also introduced new mucocutaneous toxicities, necessitating regular monitoring and supportive care.

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