Cold Thermal Injury from Cold Caps Used for the Prevention of Chemotherapy-Induced Alopecia

The document discussed the occurrence of cold thermal injuries (frostbite) from using cold caps to prevent chemotherapy-induced alopecia (CIA). It reported on four patients who experienced mild to moderate injuries, which improved with topical treatments, though three had mild persistent alopecia. The injuries were linked to improper application, such as inadequate padding and prolonged cooling. The study highlighted the lack of standardized guidelines and regulatory oversight, suggesting the need for further research and standardized protocols to prevent adverse events and understand long-term risks. It emphasized the importance of proper patient and nurse education, screening programs, and personnel training to optimize outcomes and minimize quality of life impairments. The research was supported by the RJR Oncodermatology Fund and the NIH/NCI Cancer Center Support Grant.