Scalp Hypothermia as a Preventative Measure for Chemotherapy-Induced Alopecia: A Review of Controlled Clinical Trials

    Vidhi V. Shah, Tongyu C. Wikramanayake, G.M. DelCanto … Joaquín J. Jiménez
    Studysummary This literature review reported that scalp hypothermia significantly decreases the occurrence of chemotherapy-induced alopecia, increasing effectiveness by 2.7-fold in controlled clinical trials and 3.9-fold in randomized trials, and highlighted a need for standard guidelines for its use.
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    Research cited in this study 12

    1. Results of Scalp Cooling During Anthracycline-Containing Chemotherapy Depend on Scalp Skin Temperature Breast · 2016
    2. Cold Thermal Injury from Cold Caps Used for the Prevention of Chemotherapy-Induced Alopecia Breast cancer research and treatment · 2016
    3. Efficacy of Interventions for Prevention of Chemotherapy-Induced Alopecia: A Systematic Review and Meta-Analysis International journal of cancer · 2014
    4. Efficacy and Tolerability of Two Scalp Cooling Systems for the Prevention of Alopecia Associated with Docetaxel Treatment Supportive Care in Cancer · 2013
    5. Pathobiology of Chemotherapy-Induced Hair Loss The Lancet Oncology · 2013
    6. Chemotherapy-Induced Alopecia Journal of the American Academy of Dermatology · 2011
    7. Treatment of Chemotherapy-Induced Alopecia Dermatologic Therapy · 2011
    8. Efficacy of Penguin Cap as Scalp Cooling System for Prevention of Alopecia in Patients Undergoing Chemotherapy Journal of Advanced Nursing · 2011
    9. Permanent Alopecia After Systemic Chemotherapy: A Clinicopathological Study of 10 Cases The American Journal of Dermatopathology · 2011
    10. Chemotherapy-Induced Alopecia: Emotional Distress and Mitigation Strategies Seminars in Cutaneous Medicine and Surgery · 2009
    11. Protection Against Chemotherapy-Induced Alopecia Pharmaceutical Research · 2006
    12. Prevention of Doxorubicin-Induced Alopecia by Scalp Hypothermia: Relation to Degree of Cooling The BMJ · 1982

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