Cutaneous Manifestations Associated With Immune Checkpoint Inhibitors

    February 2023 in “ Frontiers in immunology ”
    Tomoya Watanabe, Yukie Yamaguchi
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    TLDR Immune checkpoint inhibitors can cause skin issues but are linked to better cancer outcomes.
    Immune checkpoint inhibitors (ICIs) used in cancer therapy can cause various cutaneous immune-related adverse events (irAEs), such as rashes, pruritus, vitiligo-like depigmentation, bullous diseases, and alopecia. These skin reactions, which occur in 30-60% of patients depending on the ICI, are linked to better tumor responses and improved survival rates, particularly in metastatic melanoma. The exact mechanisms are unclear but may involve T cell activation and proinflammatory cytokines. Effective management of these dermatologic toxicities, including the use of corticosteroids and immunomodulators, is crucial for patient comfort and continued treatment efficacy.
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