Cutaneous Manifestations Associated With Immune Checkpoint Inhibitors

    February 2023 in “ Frontiers in immunology ”
    Tomoya Watanabe, Yukie Yamaguchi
    Image of study
    TLDR Immune checkpoint inhibitors can cause skin issues but are linked to better cancer outcomes.
    Immune checkpoint inhibitors (ICIs) used in cancer therapy can cause various cutaneous immune-related adverse events (irAEs), such as rashes, pruritus, vitiligo-like depigmentation, bullous diseases, and alopecia. These skin reactions, which occur in 30-60% of patients depending on the ICI, are linked to better tumor responses and improved survival rates, particularly in metastatic melanoma. The exact mechanisms are unclear but may involve T cell activation and proinflammatory cytokines. Effective management of these dermatologic toxicities, including the use of corticosteroids and immunomodulators, is crucial for patient comfort and continued treatment efficacy.
    Discuss this study in the Community →

    Research cited in this study

    3 / 3 results

    Related Community Posts Join

    6 / 229 results

      community ~3 year update on my singular DHT immune hair for you guys

      in Update  21 upvotes 1 year ago
      The post is an update on the user's hair loss journey. They have a strong hair follicle that has remained unaffected by hair loss for almost 3 years. The user is starting finasteride and using ketoconazole, alfatradiol, and oral castor oil for hair maintenance.

      community Why does MPB only affect the scalp

      in Research/Science  14 upvotes 3 days ago
      Male pattern baldness (MPB) may be influenced by androgen receptors in scalp hair follicles and potentially poor blood flow. Transplanted hair is not immune to DHT, and factors like inflammation and scalp tension might also contribute to hair loss.

      community The ultimate regiment to reverse hairloss

      in Treatment  6 upvotes 1 year ago
      The conclusion of the conversation is that the user "Shakalakaplaka" shares their comprehensive hair loss regimen, which includes various treatments targeting different pathways such as DHT, inflammation, fibrosis, immune system, testosterone, gut problems, and scalp health. The effectiveness of the regimen is not confirmed, and some users express skepticism or request before and after pictures for credibility.

      community Autoimmune issue?

      in Question  2 upvotes 6 years ago
      The user experienced severe hair loss, itchy scalp, and skin issues after trying no-shampoo, and wonders if it's male pattern baldness or an immune issue. They have a history of eczema, dermatitis, and jock itch, and have tried various treatments like coconut oil, peppermint, pumpkin seed, and onion.

    Similar Research

    5 / 1000+ results