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research Hair follicle-inspired therapies for wound healing and scar remodelling

2 citations , July 2025 in “Journal of Plastic Reconstructive & Aesthetic Surgery”

This review discusses the role of hair follicles in wound healing and scar remodeling, emphasizing that hair follicle transplantation may aid in faster wound closure and scar reduction by enhancing the cellular and molecular mechanisms involved in scarring.

research Hair follicle micro-particle skin grafting induces scar remodeling via PI3K-AKT signaling: a randomized clinical trial

August 2026 in “npj Regenerative Medicine”

This study found that hair follicle micro-graft transplantation significantly improved scar remodeling outcomes in 40 patients, with greater reductions in scar volume, lower scar scores, and enhanced skin characteristics compared to punch excision alone, potentially due to activation of the PI3K-AKT pathway.

research Cell-free adipose extract inhibits hypertrophic scar formation through collagen remodeling and antiangiogenesis

January 2025 in “Open Medicine”

This study found that high-concentration cell-free adipose extract effectively reduced collagen deposition and blood vessel formation in a rabbit ear model, showing promise for preventing and treating hypertrophic scars.

Staged Hair Transplantation in Face and Scalp Scars After Carbon Dioxide Laser or Platelet-Rich Plasma-Assisted Scar Tissue Remodeling

research Staged Hair Transplantation in Face and Scalp Scars after Carbon Dioxide Laser or Platelets Rich Plasma-Assisted Scar Tissue Remodeling

July 2025 in “The Egyptian Journal of Hospital Medicine”

This study concluded that preparing scars with either platelet-rich plasma or CO₂ laser significantly improved outcomes in hair transplantation for patients with cicatricial alopecia.

research Effects of ginsenoside Rb1 on hypertrophic scar remodeling in rabbit model

10 citations , January 2015 in “European journal of pharmacology”

In this animal study, ginsenoside Rb1 demonstrated therapeutic effects on hypertrophic scar remodeling, with the highest efficacy observed at a dose of 0.56 mg.

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Community Join

5 / 302 results

community Could microneedling for the next 5 years cause any permanent damage?

in Microneedling 22 upvotes 3 years ago

Microneedling for hair loss and its potential long-term effects. Some users believe it can cause fibrosis and scar tissue if done too frequently or deeply, while others claim it has improved their hair loss when done correctly. There is limited scientific research on the topic.

community Microneedling scarring or not? Doesn't it make the situation worse?

in Microneedling 6 upvotes 1 year ago

Microneedling can help with hair loss by inducing collagen if done correctly, but improper technique may cause scarring and worsen the condition. Some users apply dissolved vitamin C before and after microneedling to enhance results.

community PP405 Won’t Work: Follicle Is Miniaturized, Fibrosed, And Missing Key Support Cells

7 months ago

PP405 is ineffective for miniaturized, fibrosed hair follicles in androgenetic alopecia. AMP303 may activate hair follicle stem cells, but minoxidil and finasteride are still the main treatments.

community Occipitalis Muscle Tension Theory

13 upvotes 7 months ago

Scalp tension from the occipitalis muscle is theorized to contribute to hair loss, but most believe DHT and genetics are the main causes. Treatments like finasteride and minoxidil are considered more effective than addressing scalp tension.

community Got my Oleic fatty acid they used in Korean study. Fuck you mice!

247 upvotes 8 months ago

Oleic acid and microneedling are being explored for hair regrowth, but results are mixed. Addressing DHT and fibrosis is crucial, with treatments like finasteride, minoxidil, and scalp massage also discussed.

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Learn

3 / 801 results

learn GHK-Cu

Heard alopecia areata leaves scar-like spots? Some peptides are helping those areas regrow hair. Alopecia areata patches usually still have living follicles. Peptides are being studied as a possible add-on, but the evidence is small and early. See a dermatologist for treatment.

learn Scalp Micropigmentation

Will my scar completely disappear after scalp micropigmentation? Scalp micropigmentation camouflages scars but does not make them completely disappear.

learn Hair Transplant

Does FUT leave a scar and is it visible? FUT leaves a linear scar that may be visible with very short hairstyles.

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Clinics

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