Polynucleotides as a Novel Therapeutic Approach in Androgenetic Alopecia: An Analysis of Effectiveness and Safety

    February 2025 in “ Archives of Dermatological Research
    Wilai Thanasarnaksorn, Nathamon Limsuchaiwat, Punyaphat Sirithanabadeekul, Sasin Charoensuksira, Atchima Suwanchinda, Jitlada Meephansan
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    TLDR Polynucleotides effectively promote hair regrowth in androgenetic alopecia without serious side effects.
    This study investigates the effectiveness and safety of polynucleotides (PN) as a treatment for androgenetic alopecia (AGA) in 28 patients. The treatment involved four injections of DOT™ PN at four-week intervals, with hair diameter and density assessed through dermoscopic analysis. Results showed significant improvements in both hair diameter and density, with notable increases one month post-treatment. Dermatologist assessments indicated stabilization in 60.7% of cases, while 82.1% of patients reported improvement, and no serious side effects were observed. The study concludes that PN effectively promotes hair regrowth in AGA patients, likely due to increased angiogenesis and anti-apoptotic effects, offering a promising alternative for those unresponsive to traditional treatments.
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